Metachromatic Leukodystrophy Adult Onset With Normal Arylsulfatase A C1835007
An adult-onset brain disorder affecting the nervous system's fatty covering. It causes progressive movement, thinking, and memory problems. No cure exists; treatment aims to manage symptoms and slow progression.
Key facts at a glance
- ICD-10
- G31.82
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Cognitive decline
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Peripheral neuropathy
(neurologic)Ataxia
(neurologic)Urinary incontinence
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Motor Function Maintenance Therapy
Physical therapy focused on preserving strength, balance, and mobility through targeted exercises and functional training to maximize independence.
Additional treatment options
Occupational Therapy
Occupational therapy to maintain upper extremity function, ADL independence, and implement assistive devices as disease progression occurs.
complementaryDisease Progression Monitoring
Regular neurologic assessments, neuroimaging, and laboratory studies to track disease progression and adjust care plans accordingly.
monitoringPsychological Support and Counseling
Psychological services including counseling and support groups to address the emotional impact of a progressive neurologic diagnosis on patients and families.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Metachromatic Leukodystrophy Adult Onset With Normal Arylsulfatase A C1835007?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy