Mhc Class I Deficiency 3 C5935618
A rare inherited immune disorder impairing cellular immune function, resulting in susceptibility to viral infections. Bone marrow transplantation may be considered in severe cases.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe mucocutaneous herpesvirus infection
Granulomatous skin lesions
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent upper respiratory tract infections
(immunologic)Chronic sinusitis
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunoglobulin Replacement
Regular immunoglobulin therapy providing broad-spectrum antibody coverage to compensate for immune dysregulation affecting antigen presentation pathways.
Antimicrobial Prophylaxis Protocol
Customized prophylactic antibiotic regimen based on individual infection history and susceptibility testing, typically including coverage for respiratory and skin pathogens.
Additional treatment options
Stem Cell Evaluation
Hematopoietic stem cell transplantation assessment for eligible patients, as this represents the only curative approach for severe immunodeficiency presentations.
procedureEnvironmental Modification
Home modifications including air filtration systems, HEPA filters, and dedicated sick room to reduce environmental pathogen load for immunocompromised individuals.
lifestyleInfection Surveillance Program
Regular surveillance cultures and imaging to detect subclinical infections before symptom onset, particularly respiratory and sinus involvement.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Mhc Class I Deficiency 3 C5935618?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy