Mitochondrial Complex Iii Deficiency Nuclear Type 6 C3809553
A genetic disorder that disrupts mitochondrial energy production in cells. It usually affects infants and young children, often impacting multiple organs. Care is primarily supportive.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Generalized fatigue
(musculoskeletal)Lactic acidosis
(metabolic)Peripheral neuropathy
(neurologic)Cardiomyopathy
(cardiovascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Comprehensive Mitochondrial Disease Monitoring
Regular surveillance including cardiac evaluation, neurological assessments, liver function tests, and metabolic panels to track disease progression and detect complications early.
Mitochondrial-Friendly Nutritional Support
Customized nutrition plan emphasizing easily metabolizable carbohydrates, adequate protein intake, and supplementation with CoQ10, L-carnitine, and B-complex vitamins to support mitochondrial function.
Additional treatment options
Symptomatic Pharmacological Management
Medications tailored to specific symptoms such as anticonvulsants for seizures, cardiac medications forhythm disorders, and agents for managing lactic acidosis.
medicationAdapted Physical Activity Program
Supervised exercise program designed to improve muscle strength and endurance while avoiding overexertion that could worsen mitochondrial dysfunction.
physical_therapyCoenzyme Q10 and Antioxidant Supplementation
Supplemental support with CoQ10, alpha-lipoic acid, and other antioxidants aimed at reducing oxidative stress and supporting electron transport chain function.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Mitochondrial Complex Iii Deficiency Nuclear Type 6 C3809553?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy