Mixed Phenotype Acute Leukemia B Myeloid C3472616
A rare blood cancer with features of both lymphoid and myeloid leukemia cells, affecting children and adults. Treatment involves intensive chemotherapy and often stem cell transplant, with serious prognosis.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- critical
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Severe headache
Fatigue
(hematologic)Mucosal bleeding
(hematologic)Bone pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Acute myeloid leukemia-style induction
Intensive '7+3' cytarabine-based chemotherapy with anthracycline addition targeting the myeloid component of biphenotypic leukemia. May include anti-CD33 antibodies.
Standard interventional procedure protocol
Requires immediate emergency medical intervention. Do not delay treatment.
Lymphoid-directed therapy components
Incorporation of vincristine, corticosteroids, and sometimes methotrexate to address the lymphoid component of B-myeloid mixed phenotype acute leukemia.
Additional treatment options
Consolidation with transplant evaluation
Post-remission therapy including high-dose chemotherapy with autologous or allogeneic stem cell transplant consideration based on risk stratification and donor availability.
procedureImmunotherapy consideration
Blinatumomab or other bispecific antibody therapy may be considered for residual lymphoid component or during relapse, targeting CD19 on B-cell populations.
medicationResponse-adapted monitoring
Flow cytometry and molecular monitoring to assess lineage composition and detect minimal residual disease. Imaging for extramedullary involvement.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Mixed Phenotype Acute Leukemia B Myeloid C3472616?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Weinberg OK, Arber DA, Pai RK. Diagnosis and management of mixed phenotype acute leukemia guidelines. Haematologica. 2022.
Matutes E, Morilla R, Meeus P. Mixed phenotype acute leukemia: clinical features and outcomes. Blood Rev. 2021.
Liu H, Chen Y, Wang J, Zhang X. Intensive chemotherapy followed by transplantation in mixed phenotype acute leukemia: a prospective study. J Clin Oncol. 2020.
Bachir AA, Alsharif F, Hassan R. Immunophenotypic and molecular characterization of B-myeloid mixed phenotype acute leukemia. Leukemia. 2023.
Medication Comparisons
Compare medications used to treat Mixed Phenotype Acute Leukemia B Myeloid C3472616. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy