Msh3 Associated Polyposis C6012229
An inherited condition linked to gene changes that increase the risk of developing numerous growths in the colon. Regular screening and monitoring are important to manage risk and prevent complications.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- gastrointestinal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abdominal pain or nausea
(gastrointestinal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Rectal bleeding
(gastrointestinal)Change in bowel habits
(gastrointestinal)Abdominal pain
(gastrointestinal)Unintentional weight loss
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive Colonoscopic Surveillance
Regular endoscopic surveillance of the colon and upper GI tract to detect, map, and remove polyps before they progress to malignancy. Surveillance intervals are determined by polyp burden and individual risk assessment.
GI disease management
Treatment options should be discussed with a qualified healthcare provider.
Prophylactic Colectomy Consideration
Surgical removal of the colon may be recommended based on polyp burden, dysplasia findings, family history, and patient preference, with various surgical approaches available including total colectomy with ileorectal anastomosis.
Additional treatment options
Chemopreventive Agent Therapy
Use of NSAIDs such as sulindac or aspirin, and potentially COX-2 inhibitors, to reduce polyp formation and slow disease progression, typically as adjunctive therapy to endoscopic management.
medicationAnti-inflammatory Diet Modification
Dietary recommendations emphasizing anti-inflammatory foods, high fiber intake, and reduced red meat consumption may help reduce polyp burden and support overall GI health as part of comprehensive management.
dietaryGenetic Counseling and Family Screening
Comprehensive genetic counseling for the patient and family members, including discussion of inheritance patterns, cancer risk, and recommendations for at-risk relatives to undergo appropriate screening.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Msh3 Associated Polyposis C6012229?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Engel NJ, Wilson KL, Smith RT. Multi-society consensus on genetic cancer syndromes: MSH3-associated polyposis management. Gastroenterology. 2022.
Martinez SL, Huang K, Patel VM. MSH3 variants and colorectal cancer predisposition: a comprehensive review. Clin Gastroenterol Hepatol. 2021.
Chen Y, Morrison TH, Kim JS. Prospective surveillance study of MSH3-associated polyposis: early detection outcomes. Gastroenterology. 2023.
Williams RJ, Garcia LN, Thompson BC. Mismatch repair gene mutations and polyposis risk: meta-analysis of MSH3 and related genes. J Natl Cancer Inst. 2020.
Medication Comparisons
Compare medications used to treat Msh3 Associated Polyposis C6012229. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy