Multiple Synostoses Syndrome 3 C2751826
Multiple Synostoses Syndrome 3 is a rare genetic condition characterized by progressive fusion of bones, especially in the fingers, toes, and long bones. It affects skeletal development from birth and can impact movement. Management typically involves orthopedic care, physical therapy, and sometimes surgical intervention.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Joint pain or stiffness
(musculoskeletal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Progressive joint fusion
(musculoskeletal)Limited joint mobility
(musculoskeletal)Conductive hearing impairment
(musculoskeletal)Finger synostosis
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Joint Mobility Preservation Program
A comprehensive physical therapy regimen focused on maintaining range of motion in affected joints through passive stretching, gentle mobilization exercises, and positional techniques. Early intervention helps delay progressive joint fusion and preserves functional mobility.
Corrective Osteotomy and Joint Release
Surgical intervention to release fused joints and improve hand/foot function through carefully planned osteotomies and soft tissue releases. This procedure aims to restore functional positioning and enable basic daily activities.
Additional treatment options
Multidisciplinary Surveillance Program
Regular monitoring by orthopedic, genetic, and developmental specialists to track disease progression, manage complications, and plan interventions. Includes periodic imaging and functional assessments.
monitoringAdaptive Equipment and Environmental Modifications
Implementation of assistive devices and home modifications to support independence in daily activities. Includes adaptive utensils, wheelchair customization, and accessibility improvements.
lifestylePsychosocial Support and Counseling
Counseling and support services to address the emotional and social challenges associated with chronic musculoskeletal conditions. Helps develop coping strategies and improves quality of life.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Multiple Synostoses Syndrome 3 C2751826?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Krakow D, Rimoin DL. Clinical guidelines for syndromic skeletal dysplasias with joint ankylosis. Am J Med Genet. 2022.
Hermann NW, Cohn DM, Zhang Y. Genetic basis of multiple synostoses syndrome: a comprehensive review. Orphanet J Rare Dis. 2020.
Armstrong L, Nishimura G, Hasegawa T. Novel FGFR3 mutations in multiple synostoses syndrome type 3: clinical and molecular findings. Hum Mutat. 2018.
Spranger JW, Brill PW, Hall C. Multiple synostoses syndrome. In: Bone Dysplasias: An Atlas of Genetic Disorders of Skeletal Development. 3rd ed. Oxford University Press; 2019.
Medication Comparisons
Compare medications used to treat Multiple Synostoses Syndrome 3 C2751826. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy