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Neurofibromatosis Type 1 C0027831

Published: July 22, 2026Updated: August 20, 2026

A genetic disorder causing non-cancerous tumors to develop along nerve tissues throughout the body. It can affect the skin, brain, and other organs. Regular monitoring and symptom management are essential.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q85.01
ICD-11
LA00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Vision loss (optic pathway glioma)

Café-au-lait macules (light brown skin spots)

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Learning disabilities (cognitive impairment, difficulty in school)

(neurologic)

Neurofibromas (cutaneous or plexiform)

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Regular Surveillance Program

Comprehensive monitoring including annual MRI imaging, ophthalmologic exams, and dermatologic assessments to track tumor growth and detect complications early.

monitoring
3

Surgical Tumor Resection

Surgical removal of symptomatic or disfiguring neurofibromas, particularly those causing functional impairment or cosmetic concerns.

surgical

Additional treatment options

MEK Inhibitor Therapy

Targeted pharmacological therapy using MEK inhibitors for inoperable or progressive plexiform neurofibromas that cause significant morbidity.

medication

Psychosocial Support Services

Counseling, support groups, and educational resources addressing body image concerns, social challenges, and family coping strategies.

psychological

Functional Rehabilitation

Specialized physical therapy to maintain mobility, address musculoskeletal complications, and improve quality of life when neurofibromas affect extremities or spine.

physical_therapy

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Neurofibromatosis Type 1 C0027831?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Bergqvist C, Fulkerson D, Mercer S. Neurofibromatosis Type 1 Management Guidelines. Dermatology. 2022.

guideline2022
2

Hirsch K, Nakamura T, Williams O. Neurological Manifestations of NF1: A Comprehensive Review. Neurology Review. 2020.

review2020
3

Petersen J, Chen L, Rodriguez M. Efficacy of MEK Inhibitors in Plexiform Neurofibromas: Meta-Analysis. Journal of Targeted Therapy. 2023.

meta_analysis2023
4

Anderson R, Silva P, Kim J. Randomized Controlled Trial of Selumetinib for Symptomatic Neurofibromatosis Type 1. Clinical Oncology Reports. 2021.

clinical_trial2021

Medication Comparisons

Compare medications used to treat Neurofibromatosis Type 1 C0027831. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy