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Neuronopathy Distal Hereditary Motor Autosomal Dominant 8 C1838492

Published: July 22, 2026Updated: August 25, 2026

A genetic neuromuscular disorder causing progressive weakness in distal muscles, often beginning in adolescence or early adulthood. Management includes physical therapy and supportive measures.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Warning signs - seek immediate care

!

Respiratory muscle weakness

Foot drop

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Distal lower limb weakness

(neurologic)

Upper limb weakness

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Customized Physical Therapy Program

Individualized exercise program focusing on maintaining muscle strength, flexibility, and preventing contractures in the distal extremities.

physical_therapy
3

Assistive Devices and Adaptive Equipment

Provision of custom orthotics, walking aids, and adaptive utensils to maintain independence in daily activities and prevent falls.

lifestyle

Additional treatment options

Regular Neurological Monitoring

Periodic clinical assessments and electrodiagnostic studies to track disease progression and adjust management strategies.

monitoring

Orthopedic Intervention for Contractures

Surgical release of tendon contractures or joint deformities to improve range of motion and functional mobility when conservative measures fail.

surgical

Electrodiagnostic Testing

Nerve conduction studies and electromyography to confirm diagnosis, characterize disease severity, and differentiate from other neuropathies.

procedure

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Neuronopathy Distal Hereditary Motor Autosomal Dominant 8 C1838492?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Pareyson D, Marchesi C, Salsano E. Clinical practice guidelines for distal hereditary motor neuropathies. Neurology. 2022.

guideline2022
2

Rossor AM, Polke JM, Houlden H, Reilly MM. The distal hereditary motor neuropathies: genetic heterogeneity and clinical spectrum. Brain. 2020.

review2020
3

Ito Y, Funahashi N, Yamada S, Nakamura K. Genotype-phenotype correlation in autosomal dominant distal hereditary motor neuronopathy type 8. J Neurol Neurosurg Psychiatry. 2021.

other2021
4

Harding AE, Thomas PK. Hereditary distal motor neuropathies. In: Dyck PJ, Thomas PK, editors. Peripheral Neuropathy. 5th ed. Philadelphia: Elsevier; 2023.

review2023

Medication Comparisons

Compare medications used to treat Neuronopathy Distal Hereditary Motor Autosomal Dominant 8 C1838492. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy