Neuronopathy Distal Hereditary Motor Type 5 C1833308
A genetic motor neuron disorder causing progressive distal muscle weakness. Inherited in an autosomal dominant pattern and managed with supportive care and rehabilitation.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Distal lower extremity weakness
(neurologic)Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hand weakness and atrophy
(neurologic)Mild sensory neuropathy
(neurologic)Scoliosis
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aquatic Therapy Program
Water-based exercises in a heated pool to reduce joint stress while maintaining muscle function and improving cardiovascular fitness with minimal impact on weakened muscles.
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Fall Prevention and Home Safety Modifications
Comprehensive home assessment and modifications including grab bars, ramps, and adaptive equipment to reduce injury risk and maintain independence.
Additional treatment options
Serial Nerve Conduction Assessments
Periodic electrodiagnostic testing to objectively measure disease progression and evaluate effectiveness of ongoing therapeutic interventions.
procedureGenetic Counseling Services
Professional genetic counseling for patients and family members to understand inheritance patterns, family planning options, and implications for relatives.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Neuronopathy Distal Hereditary Motor Type 5 C1833308?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Rossor AM, Polvikoski K, Houlden H. Consensus recommendations on the diagnosis and management of hereditary motor neuropathies. Neurology. 2022.
Feng Y, Chen L, Liu D. Genotype-phenotype correlations in distal hereditary motor neuropathies. Neuromuscular Disorders. 2021.
Sullivan R, Kwon J, Patel R. Clinical and molecular characterization of BSCL2 mutations in distal hereditary motor neuropathy type V. Brain. 2020.
Williams CA, Garcia Sanchez C, Thompson M. Therapeutic approaches in hereditary motor neuropathies: a systematic review and meta-analysis. Journal of Neurology Neurosurgery and Psychiatry. 2023.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy