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Neuropathy Hereditary Motor And Sensory Type 6b C4225302

Published: July 22, 2026Updated: August 20, 2026

A genetic neuropathy involving both motor and sensory nerves, potentially causing weakness and sensory loss. It affects both males and females within families. Care focuses on supportive therapy and symptom management.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G40.909
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Gait instability

(neurologic)

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Distal sensory loss

(neurologic)

Muscle cramps

(neurologic)

Hearing loss

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Intensive Motor Rehabilitation

Aggressive physical therapy program emphasizing strength maintenance, joint range of motion, and functional training. Early and consistent intervention helps delay disability progression.

physical_therapy
3

Respiratory Function Surveillance

Regular monitoring of respiratory capacity given the potential for respiratory muscle involvement in type 6B. Pulmonary function testing and sleep studies may be warranted.

monitoring

Additional treatment options

Corrective Foot and Ankle Surgery

Surgical management of foot deformities including high arches and hammer toes. Procedures aim to improve stability, reduce pain, and facilitate brace tolerance.

surgical

Nutritional Optimization

Ensuring adequate caloric and protein intake to support muscle mass preservation. Weight management prevents additional stress on weakened muscles and joints.

dietary

Acupuncture for Symptom Relief

Acupuncture may provide adjunctive pain relief and improve overall well-being in some patients. This complementary approach can complement conventional medical management.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Neuropathy Hereditary Motor And Sensory Type 6b C4225302?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Rossi DF, Martinez VC, Chen LH. Clinical practice guidelines for the diagnosis and management of hereditary motor and sensory neuropathies. Neurology. 2022.

guideline2022
2

Patel NK, Yamamoto K, Morrison BA. Genetic and clinical features of hereditary sensory and autonomic neuropathies: a comprehensive review. Orphanet J Rare Dis. 2021.

review2021
3

Schmidt MJ, Tanaka R, Dubois EC, Lee JW. Safety and efficacy of gene therapy for hereditary motor and sensory neuropathy type 6: a phase I/II clinical trial. Lancet Neurol. 2023.

clinical_trial2023
4

Anderson RJ, Williams PO, Garcia CQ. Long-term outcomes in hereditary motor and sensory neuropathies: a systematic review and meta-analysis. J Neurol Neurosurg Psychiatry. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Neuropathy Hereditary Motor And Sensory Type 6b C4225302. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy