Osteogenesis Imperfecta And A Reduction Of Bone Mineral Density Cn315660
A genetic condition causing fragile, easily fractured bones and reduced bone density. It affects both males and females, with treatment focused on fracture prevention and bone strength.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Multiple bone fractures with minimal trauma
Joint pain or stiffness
(musculoskeletal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Blue-gray discoloration of the sclerae
(musculoskeletal)Short stature due to skeletal abnormalities
(musculoskeletal)Generalized joint hypermobility
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Bisphosphonate therapy
Bisphosphonates such as pamidronate or zoledronic acid are used to increase bone mineral density and reduce fracture risk by inhibiting osteoclast activity.
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Calcium and vitamin D supplementation
Adequate calcium and vitamin D intake supports bone mineralization and complements pharmacologic therapy for optimal bone health.
Additional treatment options
Intramedullary rodding
Surgical placement of intramedullary rods provides internal support for long bones, reducing fracture risk and correcting deformities in weight-bearing bones.
surgicalSafe mobility and exercise program
Supervised physical therapy focusing on low-impact exercises, swimming, and proper body mechanics helps maintain muscle strength without excessive bone stress.
physical_therapyRegular skeletal assessment
Periodic bone density scans, radiographic monitoring, and fracture tracking help guide treatment decisions and assess disease progression.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Osteogenesis Imperfecta And A Reduction Of Bone Mineral Density Cn315660?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Forlino A, Marini JC. Osteogenesis imperfecta. Nat Rev Dis Primers. 2021.
Rauch F, Glorieux FH. Osteogenesis imperfecta. Lancet. 2020.
Orwoll ES, Shapiro J, Veigh S, et al. Bisphosphonate therapy in osteogenesis imperfecta: a randomized controlled trial. J Bone Miner Res. 2022.
Dwan K, Phillipi CA, Steiner RD, Basel D. Bisphosphonate therapy for osteogenesis imperfecta. Cochrane Database Syst Rev. 2020.
Medication Comparisons
Compare medications used to treat Osteogenesis Imperfecta And A Reduction Of Bone Mineral Density Cn315660. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy