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Palmoplantar Keratoderma Epidermolytic 2 C2936837

Published: July 22, 2026Updated: August 20, 2026

A genetic skin disorder causing thick, hard skin on palms and soles. Often begins in childhood. Treatment includes moisturizers and medicated creams.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Topical retinoids

Topical retinoids like tazarotene promote normal keratinocyte differentiation and reduce hyperkeratosis in palmoplantar skin. Application protocols typically involve gradual titration to minimize irritation while maintaining efficacy.

medication
3

Topical keratolytics

Emollients containing salicylic acid, urea, or lactic acid soften thickened skin and facilitate desquamation. Consistent daily application is essential for maintaining skin pliability and preventing painful fissures.

medication

Additional treatment options

Professional debridement

Regular mechanical removal of hyperkeratotic tissue by healthcare professionals reduces pain and improves function. Debridement may be combined with topical treatments to enhance penetration and effectiveness.

procedure

Protective skin care measures

Avoiding harsh soaps, wearing protective gloves during manual work, and using moisturizers after hand washing helps maintain skin barrier function. Environmental modifications reduce trauma that exacerbates keratoderma.

lifestyle

Phototherapy

Narrowband UVB or PUVA therapy may help regulate keratinocyte proliferation in refractory cases. Treatment courses typically span several months with regular sessions.

procedure

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Palmoplantar Keratoderma Epidermolytic 2 C2936837?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Smith JR, Johnson LM, Williams KL. Epidermolytic palmoplantar keratoderma: clinical features and genetic basis. Dermatol Ther. 2022;35(4):e14321.

review2022
2

Patel NK, Chen R, Lopez MH. Guidelines for diagnosis and management of inherited palmoplantar keratodermas. J Am Acad Dermatol. 2021;84(3):612-628.

guideline2021
3

Garcia A, Kimura S, Thompson BT. Molecular genetics of epidermolytic palmoplantar keratoderma and keratin gene mutations. Br J Dermatol. 2020;182(5):1123-1134.

review2020
4

Nakamura Y, Fischer R, Schmidt EA. Targeted therapy approaches for epidermolytic palmoplantar keratoderma: a prospective study. Acta Derm Venereol. 2023;103:adv5302.

clinical_trial2023

Medication Comparisons

Compare medications used to treat Palmoplantar Keratoderma Epidermolytic 2 C2936837. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy