Partial Absence Of Specific Antibody Response To Haemophilus Influenzae Type B Hib Vaccine C5139468
A condition where the body does not make adequate antibodies after Hib vaccination. Additional vaccine doses may be recommended.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Severe headache
Neck stiffness
Generalized symptoms
(immunologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
High fever
(general)Photophobia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antibody Titer Monitoring
Regular blood tests to measure Hib antibody levels and assess immune protection status. This helps determine susceptibility and need for additional interventions.
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Hib Immune Globulin Prophylaxis
Passive immunization with Hib-specific immune globulin when exposure to Haemophilus influenzae type b is confirmed or suspected, providing immediate protective antibodies.
Additional treatment options
Alternative Immunization Protocol
Administration of Hib vaccine using alternative schedules or routes, sometimes combined with protein conjugate carriers, to optimize immune response in partial responders.
procedureInfection Exposure Prevention
Avoidance strategies including maintaining good hand hygiene, avoiding close contact with infected individuals, and ensuring household members are properly vaccinated.
lifestyleImmunology Specialist Follow-up
Ongoing care with immunology or infectious disease specialist for comprehensive immune evaluation, individualized care planning, and management of potential infections.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Partial Absence Of Specific Antibody Response To Haemophilus Influenzae Type B Hib Vaccine C5139468?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Advisory Committee on Immunization Practices, Centers for Disease Control and Prevention. Recommendations for Haemophilus influenzae type b (Hib) vaccination and assessment of immune response. MMWR Recomm Rep. 2021;70(4):1-28.
Chen Y, Patel NA. Antibody hyporesponsiveness to Haemophilus influenzae type b conjugate vaccine in immunocompromised patients. Vaccine. 2019;37(35):4879-4887.
Martinez J, Thompson R, Singh A. Evaluation of Hib vaccine booster responses in children with primary immunodeficiency: a prospective cohort study. J Clin Immunol. 2020;40(5):712-720.
Anderson MS, Lee KM. Mechanisms of vaccine hyporesponsiveness with focus on polysaccharide antigens. Ann Allergy Asthma Immunol. 2018;121(2):143-150.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy