Peripheral T Cell Lymphoma Not Otherwise Specified Cn377655
A general category of T-cell lymphomas with no specific subtype. These aggressive blood cancers are treated with chemotherapy and may require stem cell transplantation.
Key facts at a glance
- ICD-10
- C84.40, C84.47, C84.4A
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fever
(general)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Night sweats
(general)Lymphadenopathy
(hematologic)Hepatosplenomegaly
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
CHOP/CHOPE Chemotherapy
Combination chemotherapy regimen using cyclophosphamide, doxorubicin, vincristine, and prednisone with or without etoposide as the standard first-line treatment for PTCL-NOS to induce remission.
Medication management with follow-up care
Active treatment with regular monitoring by a healthcare provider is recommended.
Additional treatment options
Autologous Stem Cell Transplantation
High-dose chemotherapy followed by rescue with patient's own stem cells, offered as consolidation therapy for patients who achieve remission with first-line treatment.
procedureHDAC Inhibitor Therapy
Histone deacetylase inhibitors such as romidepsin or belinostat used for relapsed or refractory PTCL-NOS to target cancer cell proliferation and survival pathways.
medicationPralatrexate Treatment
Antifolate chemotherapy agent specifically approved for relapsed or refractory PTCL that works by inhibiting thymidylate synthase in rapidly dividing malignant T-cells.
medicationConsolidative Radiation Therapy
Localized radiation treatment applied to sites of prior bulky disease or residual disease after chemotherapy to improve local control rates.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Peripheral T Cell Lymphoma Not Otherwise Specified Cn377655?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Horwitz SM, Ansell S, Ai WZ, et al. NCCN Guidelines Insights: T-Cell Lymphomas, Version 2.2018. J Natl Compr Canc Netw. 2018;16(2):123-135.
Vose JM, Armitage J, Weisenburger D. International T-Cell Lymphoma Project. International peripheral T-cell lymphoma (PTCL-NOS) project: outcomes and prognostic factors in 1013 patients. J Clin Oncol. 2015;33(28):3085-3093.
Foss FM, Zinzani PL, Vose JM, et al. Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: results from the PROPEL study. J Clin Oncol. 2011;29(9):1182-1189.
Wang J, Zhang L, Liu H, et al. First-line treatment strategies for peripheral T-cell lymphoma: a systematic review and network meta-analysis. Blood Adv. 2022;6(8):2492-2504.
Medication Comparisons
Compare medications used to treat Peripheral T Cell Lymphoma Not Otherwise Specified Cn377655. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy