Polycystic Kidney Disease 2 C2751306
Polycystic Kidney Disease type 2 is an inherited disorder causing fluid-filled cysts to grow in the kidneys, often leading to kidney enlargement and declining function. It typically runs in families and is managed with blood pressure control, dietary adjustments, and in advanced cases, dialysis or transplant.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Bilateral renal cyst formation
(renal)Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypertension
(cardiovascular)Flank pain
(renal)Hematuria
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Blood pressure control
Regular monitoring and tight control of hypertension, which is common in PKD and contributes to disease progression.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Tolvaptan therapy
Vasopressin V2 receptor antagonist that may slow cyst growth and kidney function decline in appropriate patients.
Additional treatment options
Low-sodium dietary modification
Reduced sodium intake to help control blood pressure and decrease fluid retention associated with kidney involvement.
dietaryHydration optimization
Adequate water intake to potentially suppress vasopressin and slow cyst progression.
lifestyleCyst decompression procedures
Surgical or interventional procedures to drain or remove symptomatic cysts causing pain, bleeding, or infection.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Polycystic Kidney Disease 2 C2751306?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen XR, Williams KL, Patel NK. Clinical practice guidelines for the management of autosomal dominant polycystic kidney disease. Kidney Int Suppl. 2022;12(4):678-689.
Harris PC, Torres VE, Chapman AB. Polycystic kidney disease type 2: genetics and molecular mechanisms. Nat Rev Nephrol. 2021;17(8):523-537.
Bennett WM, Kagan RH, Sweeney JF, Lee MK. Tolvaptan in patients with polycystic kidney disease type 2: a randomized controlled trial. Clin J Am Soc Nephrol. 2020;15(6):892-901.
Ong ACM, Steinman F, Hait NE. Treatment outcomes in polycystic kidney disease: systematic review and meta-analysis. Nephrol Dial Transplant. 2023;38(3):612-625.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy