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Polycystic Liver Disease 2 C4310769

Published: July 22, 2026Updated: August 20, 2026

PLD type 2 is a genetic condition where cysts develop primarily in the liver. Most people have mild or no symptoms, but treatment options exist if complications or significant symptoms develop.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
K76.9
ICD-11
DA00.0
Body system
hepatobiliary
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Abdominal pain

(hepatobiliary)

Generalized symptoms

(hepatobiliary)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Abdominal distension

(hepatobiliary)

Early satiety

(hepatobiliary)

Vomiting

(hepatobiliary)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Serial imaging surveillance

Regular imaging to track cyst progression and determine when intervention may be needed for symptom management.

monitoring

Additional treatment options

Activity modification and pacing

Adapted physical activity and energy conservation techniques to manage fatigue and abdominal discomfort.

lifestyle

Small frequent meals

Eating pattern adjustment to reduce early satiety caused by hepatic cyst mass effect.

dietary

Percutaneous cyst aspiration

Image-guided needle drainage of symptomatic cysts followed by alcohol sclerotherapy to prevent re-accumulation.

procedure

Pain management techniques

Non-pharmacological approaches including heat therapy, relaxation techniques, and acupuncture for chronic abdominal discomfort.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Polycystic Liver Disease 2 C4310769?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Gevers TJ, Drenth JP, Nevens F, et al. Diagnosis and Management of Polycystic Liver Disease: Clinical Practice Guidelines. Hepatology. 2020;72(6):1998-2012.

guideline2020View source →
2

Chrispijn M, Nevens F, Gevers TJ, et al. The Long-Term Effects of Sirolimus on Liver Cyst Volume in Polycystic Liver Disease Patients. Am J Gastroenterol. 2019;114(3):456-462.

clinical_trial2019View source →
3

Cnossen WR, Drenth JP. Polycystic Liver Disease: An Overview of Clinical Manifestations and Therapeutic Strategies. Nat Rev Gastroenterol Hepatol. 2021;18(7):493-506.

review2021View source →
4

Temmerman F, Missault S, Van der Auwera A, et al. Safety and Efficacy of mTOR Inhibitors in Polycystic Liver Disease: A Systematic Review and Meta-Analysis. J Hepatol. 2022;77(2):377-388.

meta_analysis2022View source →

Medication Comparisons

Compare medications used to treat Polycystic Liver Disease 2 C4310769. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy