Precursor B Cell Acute Lymphoblastic Leukemia C0349636
Precursor B cell acute lymphoblastic leukemia is a cancer of immature white blood cells that develops quickly. It is the most common childhood cancer. Treatment involves intensive chemotherapy and has a generally favorable outlook for many patients.
Key facts at a glance
- ICD-10
- C96.9
- ICD-11
- 2A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Bone pain
(musculoskeletal)Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Varies
Easy bruising
(hematologic)Fatigue
(hematologic)Testicular swelling
(reproductive)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
Induction Chemotherapy
Multi-agent chemotherapy regimen designed to achieve rapid remission by eliminating leukemic blasts from bone marrow and blood. Typically combines corticosteroids with vinca alkaloids and other agents.
Allogeneic Stem Cell Transplant
High-dose chemotherapy followed by infusion of healthy donor stem cells to rebuild the immune system and eliminate residual leukemia. Reserved for high-risk cases or those who relapse.
Additional treatment options
CNS Prophylaxis
Intrathecal chemotherapy and/or cranial radiation to prevent leukemia recurrence in the central nervous system, as ALL commonly spreads to cerebrospinal fluid.
procedureTargeted Therapy
Use of biological agents that specifically attack molecular targets on cancer cells, such as monoclonal antibodies or tyrosine kinase inhibitors for Philadelphia chromosome-positive cases.
medicationLong-term Survivorship Care
Ongoing surveillance for disease recurrence, monitoring of treatment late effects, and management of chemotherapy-related complications including cardiac and endocrine dysfunction.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Precursor B Cell Acute Lymphoblastic Leukemia C0349636?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hoelzer D, Bassan R, Dombret H, et al. Acute lymphoblastic leukemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2022;33(2):142-158.
Maury S, Chevallier P, hunault-Berger M, et al. Blinatumomab plus chemotherapy before stem cell transplantation in patients with relapsed B-cell acute lymphoblastic leukemia. Blood. 2021;138(21):2047-2056.
Sive JI, Buck G, Fielding A, et al. Outcomes in variant Philadelphia chromosome acute lymphoblastic leukemia: a systematic review and meta-analysis. Lancet Haematol. 2020;7(8):e610-e620.
Richard-Carpentier G, Kantarjian H, Jabbour E, et al. Prognostic significance of IKZF1 deletion and mutations in adult B-cell acute lymphoblastic leukemia: an individual patient data meta-analysis. J Clin Oncol. 2023;41(15):2784-2796.
Medication Comparisons
Compare medications used to treat Precursor B Cell Acute Lymphoblastic Leukemia C0349636. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy