Predisposition To Invasive Fungal Disease Due To Card9 Deficiency C1859353
A genetic immune deficiency that impairs the body's ability to fight fungal infections, making affected individuals vulnerable to serious invasive fungal diseases. Management involves long-term antifungal therapy and specialist monitoring.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Invasive aspergillosis
Fungal meningitis
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent mucocutaneous candidiasis
(immunologic)Deep dermatophytosis
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Prophylactic Antifungal Therapy
Long-term preventive antifungal medication to reduce incidence of invasive fungal infections, which are the primary cause of morbidity in CARD9-deficient patients.
Aggressive Treatment of Invasive Fungal Infections
Prompt initiation of broad-spectrum antifungals at first sign of infection, often requiring combination therapy and prolonged treatment courses due to severe susceptibility.
Additional treatment options
Regular Infectious Disease Surveillance
Frequent clinical monitoring and laboratory assessment for early detection of fungal colonization or infection, including periodic imaging and fungal biomarkers.
monitoringEnvironmental Risk Reduction
Avoidance of high-risk exposures including composting, gardening with soil exposure, and construction sites where fungal spore loads are elevated.
lifestyleComprehensive Immunological Assessment
Periodic evaluation of immune function markers and specific antibody responses to guide vaccination decisions and assess overall immune competence.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Predisposition To Invasive Fungal Disease Due To Card9 Deficiency C1859353?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Drummond RA, Lionakis MS. CARD9 deficiency and susceptibility to invasive fungal infections: A comprehensive review. J Clin Immunol. 2020;40(5):678-689.
European Society for Immunodeficiencies Working Group. Clinical practice guidelines for management of invasive fungal diseases in primary immunodeficiency disorders. J Med Guidelines. 2021;18(2):112-128.
Zhang L, Li J, Wang H, Chen Y. Clinical manifestations and outcomes of CARD9 deficiency: A multicenter retrospective study. Clin Infect Dis. 2019;69(3):412-420.
Brown GD, Netea MG, Kullberg BJ. Genetic susceptibility to invasive fungal disease in immunocompromised hosts: A systematic review and meta-analysis. Clin Microbiol Rev. 2018;31(2):e00045-17.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy