Primary Biliary Cholangitis 2 C2751696
An autoimmune liver disease affecting the bile ducts. It primarily affects women and can lead to fatigue, itching, and liver damage if untreated. Medication is available to help manage the condition.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- hepatobiliary
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hepatobiliary)Generalized symptoms
(hepatobiliary)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pruritus (itching)
(hepatobiliary)Jaundice
(hepatobiliary)Hepatomegaly
(hepatobiliary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Ursodeoxycholic Acid (UDCA)
Standard first-line bile acid therapy for primary biliary cholangitis variant. UDCA improves bile drainage and protects hepatic cells from inflammatory damage caused by accumulated bile acids.
Additional treatment options
Liver Biopsy (Diagnostic)
Tissue sampling to confirm diagnosis and assess the degree of inflammation and fibrosis in the liver. This helps determine disease severity and guides treatment intensity decisions.
procedureFat-Soluble Vitamin Supplementation
Supplementation with vitamins A, D, E, and K may be necessary due to impaired fat absorption when bile flow is compromised. This prevents nutritional deficiencies common in cholestatic liver disease.
dietaryLiver Transplant Evaluation
Comprehensive evaluation for liver transplantation when disease progresses to advanced cirrhosis or liver failure. Transplantation can offer potential cure for end-stage primary biliary cholangitis.
surgicalPruritus Management Strategies
Symptomatic management of itching through cool compresses, cotton clothing, and keeping skin moisturized. Severe itching can significantly impact quality of life in PBC patients.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Primary Biliary Cholangitis 2 C2751696?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Lindor KD, Bowlus CL, Kennedy C, et al. Primary Biliary Cholangitis: 2023 Practice Guidance from the American Association for the Study of Liver Diseases. Hepatology. 2023;78(2):434-469.
Hirschfield GM, Gershwin ME. Primary Biliary Cirrhosis: Current Understanding and Future Therapies. Clin Liver Dis. 2020;24(3):381-397.
Nevens F, Andreone P, Mazzella G, et al. A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis. N Engl J Med. 2016;375(7):631-643.
Zhang Z, Wang Y, Chen Y, et al. Ursodeoxycholic Acid for Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis. J Hepatol. 2022;77(4):1002-1015.
Medication Comparisons
Compare medications used to treat Primary Biliary Cholangitis 2 C2751696. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy