Primary Biliary Cholangitis 3 C2751695
A chronic autoimmune condition that damages the liver's bile ducts over time. It mainly occurs in women and may progress without treatment. Regular monitoring and medication can help control symptoms.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- hepatobiliary
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hepatobiliary)Generalized symptoms
(hepatobiliary)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Pruritus
(hepatobiliary)Xanthelasma
(hepatobiliary)Jaundice with weight loss
(hepatobiliary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Ursodeoxycholic Acid Monotherapy
Primary pharmacological intervention using UDCA to enhance bile secretion and reduce liver inflammation. This remains the cornerstone of treatment for this PBC variant with documented efficacy in slowing fibrosis progression.
Additional treatment options
Fibrate Combination Therapy
Addition of bezafibrate or fenofibrate to UDCA in incomplete responders. These peroxisome proliferator-activated receptor agonists may improve biochemical response in selected patients.
medicationMilk Thistle (Silymarin) Support
Herbal supplement sometimes used as complementary support for liver function. While evidence is limited, some patients report subjective improvement in fatigue and well-being.
complementaryEnhanced Fibrosis Monitoring
Serial non-invasive fibrosis assessment using elastography (FibroScan) to track disease progression. This allows for early identification of cirrhotic changes requiring intensified management.
monitoringChronic Disease Counseling
Psychological support addressing the chronic nature of PBC and associated fatigue. Cognitive behavioral approaches can help patients develop coping strategies for managing uncertainty and treatment adherence.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Primary Biliary Cholangitis 3 C2751695?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Hirschfield GM, Gershwin ME. American Association for the Study of Liver Diseases Practice Guidelines for Primary Biliary Cholangitis. Hepatology. 2021.
Lleo A, Wang GQ, Gershwin ME, Invernizzi P. Primary biliary cholangitis: a comprehensive review. J Hepatol. 2020.
Nevens F, Andreone P, Mazzella G. A randomized controlled trial of obeticholic acid monotherapy in patients with primary biliary cholangitis. Gastroenterology. 2019.
Zhang L, Liu J, Wang J. Efficacy and safety of fibrates for primary biliary cholangitis: a systematic review and meta-analysis. Hepatology. 2022.
Medication Comparisons
Compare medications used to treat Primary Biliary Cholangitis 3 C2751695. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy