Primary Cutaneous B Cell Lymphoma C1274310
A rare cancer where abnormal white blood cells grow in the skin, appearing as bumps or patches. Treatment may include radiation, chemotherapy, or targeted therapy.
Key facts at a glance
- ICD-10
- C83.390
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Cutaneous nodule
(integumentary)Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Cutaneous plaque
(integumentary)Pruritus
(integumentary)Skin ulceration
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Localized Radiation Therapy
Low-dose radiotherapy targeting individual skin lesions, particularly effective for primary cutaneous B-cell lymphoma of the leg type or recurrent disease. Treatment is carefully planned to minimize radiation exposure to surrounding tissue.
Surgical Excision
Complete surgical removal of solitary or localized skin lesions with appropriate margins. Often combined with radiation therapy for enhanced local control in higher-risk presentations.
Additional treatment options
Topical Therapy
Application of topical agents such as corticosteroids, nitrogen mustard, or retinoids for early-stage or multifocal disease. Useful for patients who prefer non-invasive options or have widespread skin involvement.
medicationPhototherapy
Narrowband UVB or PUVA therapy for widespread cutaneous disease, offering treatment to multiple lesions simultaneously with cumulative dosing schedules. Requires regular clinic visits for administration.
procedureStaged Skin Examination and Imaging
Regular whole-body skin examinations with dermoscopy and periodic imaging studies to assess treatment response and detect disease progression or transformation. Includes documentation of all lesions with photography.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Primary Cutaneous B Cell Lymphoma C1274310?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Willemze R, Hodak E, Zinzani PL, et al. Primary cutaneous lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2018.
Kempf W, Denisjuk N, Kerl K, et al. Primary cutaneous B-cell lymphomas: an update on classification, clinical features, and diagnostic approach. J Eur Acad Dermatol Venereol. 2020.
Valencak J, Ruzicka T, Massone C. Rituximab for primary cutaneous B-cell lymphoma: a retrospective analysis of 45 patients. Br J Dermatol. 2019.
Senff NJ, Hoekzema R, Nico MM, et al. Fluorescence in situ hybridization for the detection of API2-MALT1 fusion in primary cutaneous marginal zone B-cell lymphoma: a systematic review. J Cutan Pathol. 2021.
Medication Comparisons
Compare medications used to treat Primary Cutaneous B Cell Lymphoma C1274310. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy