Primary Cutaneous Cd30 T Cell Lymphoproliferative Disease C5679826
A disorder where immune cells accumulate in the skin, forming bumps or patches. Most cases are slow-growing and respond well to localized treatments.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Cutaneous papule
(integumentary)Generalized symptoms
(oncologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Cutaneous nodule
(integumentary)Pruritus
(integumentary)Lesion ulceration
(integumentary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Active Surveillance
Close observation without immediate intervention for limited or regressing lesions, recognizing the often-indolent nature of CD30+ lymphoproliferative disorders. Regular examinations and photography documentation track any disease progression.
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Topical or Intralesional Corticosteroids
High-potency topical steroids or intralesional corticosteroid injections directly into lesions for local control with minimal systemic effects. Often first-line for symptomatic or cosmetically concerning lesions.
Additional treatment options
Low-Dose Radiation Therapy
Very low-dose radiation therapy effective for individual lesions that are symptomatic, persistent, or cosmetically problematic. Well-tolerated with excellent response rates in this typically radiosensitive condition.
procedureMethotrexate Therapy
Low-dose oral or subcutaneous methotrexate for patients with widespread or recurrent disease requiring systemic intervention. Provides disease control with a favorable safety profile at low doses.
medicationExcisional Biopsy for Diagnosis and Treatment
Complete surgical removal of a representative lesion both for definitive diagnosis and therapeutic benefit, particularly when lesions are isolated and accessible. Provides tissue for complete histological evaluation.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Primary Cutaneous Cd30 T Cell Lymphoproliferative Disease C5679826?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Willemze R, Hodak E, Zychowska M, Berti E. Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorders: ESMO Clinical Practice Guidelines. Ann Oncol. 2021;32(5):642-655.
Kempf W, Denisjuk N, Kerl B, et al. Cutaneous CD30+ T-Cell Lymphoproliferative Disorders: Updates and Current Concepts. Br J Dermatol. 2019;180(6):1347-1359.
Liu H, Vergilis-Brandqvist E, Gniadecki R, et al. Long-term Outcomes of Brentuximab Vedotin in Primary Cutaneous Anaplastic Large Cell Lymphoma. JAMA Dermatol. 2020;156(10):1085-1092.
Savage KJ, Ferreri AJ, Zinzani PL, Pileri SA. Therapeutic Outcomes in Primary Cutaneous CD30+ Lymphoproliferative Disorders: A Systematic Review and Meta-Analysis. J Clin Oncol. 2018;36(32):3230-3241.
Medication Comparisons
Compare medications used to treat Primary Cutaneous Cd30 T Cell Lymphoproliferative Disease C5679826. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy