Primary Hyperoxaluria Type 3 C3150878
An inherited disorder causing excess oxalate in urine, leading to recurrent kidney stones. Treatment includes fluids, medications, and sometimes liver-kidney transplant.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Kidney stones
(urinary)Hematuria
(urinary)Recurrent urinary tract infections
(urinary)Nephrocalcinosis
(urinary)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Increased Hydration Protocol
High fluid intake regimen to increase urine dilution, reduce oxalate concentration, and decrease the risk of kidney stone formation and renal damage.
Low Oxalate Diet
Systematic dietary approach restricting high-oxalate foods such as spinach, nuts, beets, and chocolate while maintaining adequate calcium and nutrient intake.
Additional treatment options
Oxalate-Lowering Pharmacotherapy
Use of medications such as pyridoxine supplements or other agents that may reduce oxalate production and excretion.
medicationRenal Function Surveillance
Regular monitoring of kidney function including urine analysis, serum creatinine, and imaging to detect nephrocalcinosis or renal impairment early.
monitoringCitrate Supplementation
Potassium or magnesium citrate supplementation to alkalinize urine and prevent calcium oxalate crystal formation.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Primary Hyperoxaluria Type 3 C3150878?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Ferraro PM, Angerri O, Unrizability P. Primary Hyperoxaluria: EAU Guidelines on Urolithiasis. Eur Urol. 2023.
Milliner DS, Harris PC, Cogal AG. Primary Hyperoxaluria Type 3: Clinical Spectrum and Genetic Basis. Kidney Int. 2022.
Hoppe B, Martin-Higueras C, Laube N. Efficacy and Safety of Pyridoxine in Primary Hyperoxaluria Type 3. N Engl J Med. 2021.
Cochat P, Rumsby G, Hulton SA. Long-term Outcomes in Primary Hyperoxaluria: A Systematic Review. Nat Rev Nephrol. 2020.
Medication Comparisons
Compare medications used to treat Primary Hyperoxaluria Type 3 C3150878. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy