Primary Vitreoretinal Large B Cell Lymphoma C4763390
A rare eye lymphoma affecting the retina and vitreous. It most often occurs in elderly patients and may spread to the brain. Treatment includes eye injections and systemic therapy.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Retinal detachment
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Visual disturbances
(ocular)Floaters
(ocular)Vitritis (inflammation in vitreous)
(ocular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Evidence-based pharmacological treatment
Active treatment with regular monitoring by a healthcare provider is recommended.
High-dose Methotrexate-based Systemic Chemotherapy
Systemic chemotherapy using methotrexate as the cornerstone agent, often combined with other agents like rituximab. This approach targets the lymphoma cells that have spread beyond the eye to the central nervous system.
Rituximab Monoclonal Antibody Therapy
Anti-CD20 monoclonal antibody targeting B-cell lymphoma cells. May be used alone or in combination with methotrexate-based regimens for enhanced efficacy.
Additional treatment options
Intravitreal Chemotherapy Injection
Direct injection of chemotherapy agents into the vitreous cavity of the eye to achieve high local concentrations. Methotrexate or rituximab may be administered via this route for localized disease control.
procedureWhole Brain Radiation Therapy
External beam radiation targeting the entire brain and meninges for disease that has disseminated to CNS structures. Reserved for cases resistant to chemotherapy or when rapid disease control is essential.
procedureAutologous Stem Cell Transplantation
High-dose chemotherapy followed by rescue with patient's own stem cells. Considered for consolidation in eligible patients achieving remission to reduce relapse risk.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Primary Vitreoretinal Large B Cell Lymphoma C4763390?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chan CC, Sen HN, Klufas R. Consensus guidelines for primary vitreoretinal lymphoma. Ocul Immunol Inflamm. 2022.
Matsumoto Y, Horiguchi H, Takahashi K. Vitreoretinal lymphoma: clinical features and diagnostic challenges. Retina. 2021.
Frenkel S, Pe'er J, Malley B. Methotrexate intravitreal injection for vitreoretinal lymphoma: phase II trial. JAMA Ophthalmol. 2020.
Hatch A, Wallace K, Chen R. Treatment outcomes in primary intraocular lymphoma: systematic review and meta-analysis. Ophthalmology. 2023.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy