Skip to content

Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions Autosomal Recessive 6 C5882731

Published: July 22, 2026Updated: August 20, 2026

A rare mitochondrial disorder causing gradual weakness of the eye muscles, leading to limited eye movement. It can also affect other muscles and is managed with supportive care.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q15.9
ICD-11
LA00.0
Body system
ophthalmologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(ophthalmologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Coenzyme Q10 (CoQ10) supplementation

CoQ10 supplementation is commonly used in mitochondrial disorders like PEO with mtDNA deletions to support mitochondrial energy production. While evidence is not definitive, some patients experience improved muscle strength and reduced fatigue.

medication
2

Healthy lifestyle changes and stress management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Targeted muscle strengthening program

Physical therapy focuses on maintaining muscle strength, improving balance, and preventing contractures. Exercises are adapted to individual tolerance levels and progressive weakness patterns.

physical_therapy

Additional treatment options

L-Carnitine supplementation

L-carnitine may help improve mitochondrial function by facilitating fatty acid transport into mitochondria for energy production. This supportive therapy can help manage muscle weakness and fatigue symptoms.

complementary

Regular neurological and ophthalmological assessments

Periodic evaluation by neurologists and ophthalmologists to monitor ptosis progression, extraocular muscle function, and peripheral neuropathy. Early intervention for complications improves outcomes.

monitoring

Ptosis surgery

Surgical correction of drooping eyelids may be necessary when ptosis significantly impairs vision or causes neck strain from compensatory head positioning. Frontalis sling procedures are commonly performed.

surgical

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions Autosomal Recessive 6 C5882731?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Mitochondrial Medicine Society. Practice Guidelines for the Management of Mitochondrial Disorders. Neurology. 2022.

guideline2022
2

Gorman GS, Schaefer AM, McFarland R. Mitochondrial DNA Deletion Disorders: From Mechanism to Therapy. Lancet Neurology. 2021.

review2021
3

Hirano M, Emmanuele V, Quinzii CM. Efficacy of Coenzyme Q10 Analogs in Patients With Progressive External Ophthalmoplegia: A Randomized Controlled Trial. JAMA Neurology. 2020.

clinical_trial2020
4

Suarez Rodriguez LC, Santorelli G, Alston CL. Systematic Review and Meta-Analysis of Genotype-Phenotype Correlations in Mitochondrial DNA Deletion Syndromes. Journal of Medical Genetics. 2019.

meta_analysis2019

Medication Comparisons

Compare medications used to treat Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions Autosomal Recessive 6 C5882731. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy