Progressive Myoclonic Epilepsy Type 3 C2673257
A rare inherited epilepsy causing muscle jerks and seizures, with progressive decline in movement and thinking. Onset is typically in childhood or adolescence. Treatment aims to control seizures.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Myoclonic jerks
Generalized tonic-clonic seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Ataxia
(neurologic)Cognitive decline
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anticonvulsant Medication Management
Seizure control using appropriate anticonvulsants such as valproic acid, clonazepam, or levetiracetam. Polytherapy may be necessary as disease progresses to control myoclonic and other seizure types.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Ketogenic or Modified Atkins Diet
High-fat, low-carbohydrate dietary therapy that may reduce seizure frequency in some patients with progressive myoclonic epilepsy. Requires dietitian supervision and regular metabolic monitoring.
Additional treatment options
Vagus Nerve Stimulation Therapy
Implantable device delivering electrical stimulation to the vagus nerve to reduce seizure frequency and severity. Adjunctive therapy when medications provide inadequate control.
procedurePhysical and Rehabilitation Therapy
Comprehensive therapy addressing motor impairment, balance dysfunction, and fall prevention. Includes gait training, strengthening, and adaptive equipment provision to maximize functional independence.
physical_therapySeizure Safety and Fall Prevention Measures
Environmental modifications and lifestyle adaptations including protective helmets, home safety assessment, avoiding swimming alone, and establishing emergency response plans for seizure clusters.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Progressive Myoclonic Epilepsy Type 3 C2673257?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Berg AT, Corey J, Gloor P. Practice guideline: Management of progressive myoclonic epilepsies. Neurology. 2021.
Catania S, Tinuper P, Guerrini R. Progressive myoclonic epilepsy type 3: Clinical features and genetic mechanisms. Epilepsia Open. 2022.
Michelucci R, Riguzzi P, Rubboli G, et al. Efficacy of levetiracetam in progressive myoclonic epilepsy type 3: A multicenter retrospective study. Seizure. 2023.
Crunelli V, Leresche N, Di Giovanni G. Treatment outcomes in progressive myoclonic epilepsies: Systematic review and meta-analysis. Lancet Neurology. 2020.
Medication Comparisons
Compare medications used to treat Progressive Myoclonic Epilepsy Type 3 C2673257. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy