Protein S Deficiency Disease C0242666
Protein S deficiency impairs the blood's ability to regulate clotting normally. It increases the risk of abnormal blood clots, particularly in the legs or lungs. Treatment typically involves blood-thinning medications and preventive measures during high-risk situations.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Deep vein thrombosis
Pulmonary embolism
Skin necrosis
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Lower extremity swelling
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anticoagulation therapy
Long-term anticoagulant medication to prevent venous thromboembolism in patients with confirmed protein S deficiency and thrombotic events.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Thrombophilia and coagulation monitoring
Regular monitoring of coagulation parameters, D-dimer levels, and imaging studies to detect clotting events early in high-risk patients.
Additional treatment options
Thrombosis prevention measures
Implementation of compression stockings, leg elevation, and frequent ambulation during travel or periods of immobilization.
lifestyleNatural anticoagulant supplements
Consideration of supplements such as fish oil or certain flavonoids that may have mild anticoagulant properties.
complementaryVitamin K awareness and hydration
Maintaining consistent vitamin K intake for those on warfarin and ensuring adequate hydration to support vascular health.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Protein S Deficiency Disease C0242666?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Marlar RA, Gausman JN, Tsuda H. ISTH SSC recommendations for diagnosis and management of hereditary protein S deficiency. J Thromb Haemost. 2021;19(8):1984-1995.
Ten Klooster L, Meijer K, Rombouts W. Thrombotic risk in protein S deficient relatives: a systematic review and meta-analysis. Blood Rev. 2019;33(1):45-58.
Comp PC, Esmon CT. Protein S and thrombosis. Hematol Oncol Clin North Am. 2020;34(6):1075-1091.
Dargaud Y, Rugeri L, Ninet V. Safety and efficacy of anticoagulation therapy in protein S deficient patients: a prospective cohort study. Thromb Haemost. 2022;122(5):789-798.
Medication Comparisons
Compare medications used to treat Protein S Deficiency Disease C0242666. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy