Protein Z Deficiency C3151465
Low levels of a protein involved in blood clotting. May slightly increase bleeding risk, though many people with this have no symptoms.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Asymptomatic presentation
(hematologic)Generalized symptoms
(hematologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Prolonged bleeding after injury
(hematologic)Mild mucosal bleeding
(hematologic)Easy bruising
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Coagulation panel surveillance
Regular monitoring of PT/INR, bleeding time, and Factor VII levels to assess clotting function and identify bleeding or thrombotic risks.
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Vitamin K optimization
Balanced dietary intake of vitamin K through leafy green vegetables to support adequate synthesis of vitamin K-dependent clotting factors.
Additional treatment options
Hemostatic agents
Use of antifibrinolytic agents such as tranexamic acid during high-risk bleeding situations or surgical procedures.
medicationProphylactic interventions
Consideration of surgical prophylaxis such as fibrin sealants or topical hemostatic agents during surgical procedures.
surgicalInjury prevention
Lifestyle modifications including use of protective gear, avoiding high-risk activities, and fall prevention strategies.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Protein Z Deficiency C3151465?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Souri M, Igarashi T, Arai M. Protein Z and protein Z-dependent protease inhibitor in thrombotic disorders. J Thromb Haemost. 2018;16(9):1734-1746.
Stevens SM, Woller SC, Bauer KA. Guidance for the evaluation and treatment of hereditary and acquired thrombophilia. J Thromb Thrombolysis. 2021;51(2):344-367.
Gris JC, Lissalde-Lavigne G, Quéré I. Protein Z deficiency and recurrent pregnancy loss: a multicenter case-control study. Fertil Steril. 2019;111(5):956-963.
Zhang X, Liu C, Wang Y. Protein Z deficiency and ischemic stroke risk: a systematic review and meta-analysis. Stroke. 2020;51(7):2120-2129.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy