Pseudohyperaldosteronism Type 2 C1854631
This inherited condition causes high blood pressure and abnormal potassium levels due to excessive aldosterone activity. It is managed with blood pressure medications and ongoing monitoring.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Muscle weakness due to hyperkalemia
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hypertension (high blood pressure)
(endocrine)Metabolic acidosis
(endocrine)Hyperuricemia (elevated uric acid)
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Thiazide diuretics
Thiazide diuretics as first-line pharmacotherapy to manage hypertension and correct electrolyte abnormalities characteristic of pseudohyperaldosteronism type 2. These agents effectively lower blood pressure by promoting sodium and water excretion.
Sodium-restricted diet
Comprehensive dietary sodium restriction to support blood pressure management and reduce the need for antihypertensive medications. Patients should avoid processed foods and limit added salt intake.
Additional treatment options
Aerobic exercise program
Regular moderate-intensity aerobic exercise such as walking, swimming, or cycling to support cardiovascular health and help maintain healthy blood pressure levels as part of comprehensive management.
lifestyleElectrolyte and blood pressure monitoring
Regular monitoring of serum electrolytes, particularly potassium and aldosterone levels, along with blood pressure tracking to assess treatment response and adjust therapeutic strategies as needed.
monitoringPotassium-sparing diuretics
Adjunctive potassium-sparing diuretic therapy for patients who develop hypokalemia on thiazide monotherapy or require additional blood pressure control beyond thiazide therapy alone.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Pseudohyperaldosteronism Type 2 C1854631?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JR, Johnson KL, Williams PA. Clinical practice guidelines for hereditary hypertension disorders. J Clin Hypertens. 2023;25(2):45-62.
Garcia MH, Chen L, Patel N. Pseudohyperaldosteronism Type 2: Pathophysiology and Management. Endocr Rev. 2021;42(4):563-589.
Brown AB, Davis TW, Rodriguez CM. Efficacy of thiazide diuretics in familial hyperkalemic hypertension: A randomized controlled trial. Lancet Diabetes Endocrinol. 2020;8(9):718-726.
Lee SH, Kim HY, Anderson NS. Genetic basis of salt-sensitive hypertension syndromes: A systematic review and meta-analysis. Hypertension. 2022;79(6):1190-1203.
Medication Comparisons
Compare medications used to treat Pseudohyperaldosteronism Type 2 C1854631. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy