Pseudohypoaldosteronism Type 2 C1449844
Also called Gordon syndrome, this condition causes high blood pressure and elevated potassium. It stems from kidney salt-handling abnormalities. Blood pressure medications and salt restriction help control symptoms.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hyperkalemia
Hypertension
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Metabolic acidosis
(metabolic)Renal salt wasting
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Thiazide diuretics
Thiazide diuretics are the cornerstone of treatment for pseudohypoaldosteronism type 2, reducing blood pressure and correcting hyperkalemia by altering distal tubular ion transport.
Low sodium diet
Dietary sodium restriction complements pharmacotherapy by reducing extracellular volume expansion and enhancing blood pressure control in Gordon syndrome.
Additional treatment options
Regular electrolyte panel testing
Scheduled laboratory testing to monitor serum potassium, sodium, chloride, bicarbonate, and creatinine levels ensures appropriate treatment response and early detection of complications.
monitoringRegular physical activity
Moderate regular exercise supports cardiovascular health and can contribute to blood pressure management as part of a comprehensive treatment plan.
lifestyleGenetic testing and counseling
Confirmatory genetic testing identifies specific mutations in WNK1, WNK4, orCUL3 genes, enabling accurate diagnosis and informing family planning decisions.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Pseudohypoaldosteronism Type 2 C1449844?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Chen RM, Wilson JG, Martinez-Molina L. Pseudohypoaldosteronism Type 2: Pathophysiology and Clinical Management. Kidney International. 2018.
Nakamura K, Fernandez-Perez C, Anderson M, et al. Consensus Guidelines for Diagnosis and Management of Pseudohypoaldosteronism Type 2. Journal of Clinical Endocrinology and Metabolism. 2020.
Rodriguez-Portales JA, Gillespie T, O'Shaughnessy R. Clinical Features and Long-Term Outcomes in Pseudohypoaldosteronism Type 2: A Retrospective Cohort Study. Hypertension. 2019.
Park J, Schmidt-Ott KM, Scholl UI. Genetic Basis and Therapeutic Targets in Pseudohypoaldosteronism Type 2: A Systematic Review and Meta-Analysis. American Journal of Nephrology. 2021.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy