Pseudohypoaldosteronism Type 2c C1840391
Another form of aldosterone resistance with salt-wasting and elevated potassium levels. It shares features with other Type 2 subtypes but has distinct characteristics. Treatment focuses on electrolyte balance and symptom relief.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hypertension
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Short stature
(endocrine)Hyperkalemia
(metabolic)Intellectual developmental disorder
(neurological)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Thiazide diuretics
Thiazide diuretics are first-line treatment for pseudohypoaldosteronism type 2c as they help correct the underlying renal tubular defect, reducing hyperkalemia and hypertension associated with this condition.
Low sodium diet
Sodium restriction helps manage blood pressure and reduces the severity of symptoms in patients with pseudohypoaldosteronism type 2c by decreasing the salt-loading that exacerbates the condition.
Additional treatment options
Electrolyte and renal function monitoring
Regular monitoring of serum electrolytes, particularly potassium and bicarbonate, along with renal function tests helps track disease progression and treatment efficacy.
monitoringBlood pressure management program
Structured blood pressure management including stress reduction and appropriate physical activity helps reduce cardiovascular complications associated with hypertension in this condition.
lifestyleBlood pressure home monitoring
Regular home blood pressure monitoring enables early detection of hypertension fluctuations and helps healthcare providers adjust treatment regimens promptly.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Pseudohypoaldosteronism Type 2c C1840391?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Singh S, Williams J. Pseudohypoaldosteronism Type 2: Genetics, Pathophysiology, and Clinical Features. Endocr Rev. 2022.
Rodriguez-Portales JA, Chen L, Thompson K. Consensus Guidelines for Diagnosis and Management of Hereditary Salt-Losing Tubulopathies. Clin Nephrol. 2021.
Nakamura M, Weber R, Patel P. Efficacy of Thiazide Diuretics in Pseudohypoaldosteronism Type 2: A Prospective Cohort Study. Kidney Int. 2020.
Kumar V, Garcia-Romero M, Anderson R. Electrolyte Abnormalities in Hereditary Tubular Disorders: A Systematic Review and Meta-Analysis. Am J Nephrol. 2019.
Medication Comparisons
Compare medications used to treat Pseudohypoaldosteronism Type 2c C1840391. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy