Pseudohypoparathyroidism Type 1b C1864100
A hormonal resistance condition where the kidneys do not respond properly to parathyroid hormone. It causes low calcium and high phosphate levels. Calcium and vitamin D supplements are typically used.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Fatigue or weight changes
(endocrine)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Muscle cramps
(endocrine)Dental enamel hypoplasia
(endocrine)Cataracts
(endocrine)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Calcium and vitamin D supplementation
Active vitamin D metabolites (calcitriol) and calcium supplements are the primary treatment, compensating for end-organ resistance to PTH and preventing hypocalcemia-related complications.
Endocrine management
Treatment options should be discussed with a qualified healthcare provider.
Serial calcium and PTH monitoring
Regular measurement of serum calcium, phosphorus, magnesium, and PTH levels guides titration of supplementation therapy and prevents complications from fluctuations.
Additional treatment options
Low phosphorus diet
Dietary phosphorus restriction helps manage hyperphosphatemia characteristic of pseudohypoparathyroidism. Patients should limit processed foods, dairy products, and phosphorus-containing additives.
dietaryThiazide diuretics
Thiazide diuretics reduce renal calcium excretion and can help maintain serum calcium levels in patients with PHP1b, complementing vitamin D and calcium supplementation.
medicationPhysical therapy for skeletal manifestations
Targeted physical therapy addresses movement limitations, muscle weakness, and skeletal abnormalities associated with pseudohypoparathyroidism, improving functional mobility and quality of life.
physical_therapyWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Pseudohypoparathyroidism Type 1b C1864100?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Moulin J, Silva-Hernandez C, Grimaldi F, et al. Clinical practice guideline for the diagnosis and management of pseudohypoparathyroidism type 1b. J Clin Endocrinol Metab. 2022.
Fernandez-Rebollo E, Lecumberri B, Turan S, et al. Molecular mechanisms of GNAS imprinting disorders in pseudohypoparathyroidism type 1b. Endocr Rev. 2021.
Nakamura A, Yoshimoto-Owada A, Katsura T, et al. Long-term outcomes of calcium and vitamin D supplementation in PHP1b patients: a multicenter retrospective study. Bone. 2020.
Huso K, Menke R, Wermers J, et al. Advances in understanding the phenotypic spectrum of pseudohypoparathyroidism type 1b. Nat Rev Endocrinol. 2023.
Medication Comparisons
Compare medications used to treat Pseudohypoparathyroidism Type 1b C1864100. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy