Rad51d Related Cancer Predisposition Cn377763
A genetic condition that predisposes individuals to cancer due to RAD51D gene mutations. It primarily affects the breast and ovaries. Management involves enhanced cancer screening and preventive measures.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Unintentional weight loss
Persistent abdominal pain
Pelvic mass
Fatigue
(oncologic)Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Comprehensive Cancer Screening Program
Regular surveillance including breast imaging, ovarian assessment, and prostate cancer screening for male carriers, following personalized risk-based protocols.
Additional treatment options
Preventive Surgical Interventions
Risk-reducing surgeries including mastectomy and/or oophorectomy discussed and offered based on individual risk assessment and family preferences.
surgicalRisk-Reducing Pharmacological Options
Evaluation for chemoprevention agents such as PARP inhibitors in certain contexts or consideration of hormonal risk reduction strategies.
medicationCancer Risk Minimization Lifestyle
Evidence-based lifestyle modifications including maintain healthy weight, regular exercise, limiting alcohol, and smoking cessation to reduce modifiable cancer risks.
lifestylePsycho-oncological Support Services
Specialized psychological support addressing cancer anxiety, family planning decisions, and coping with hereditary risk awareness.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Rad51d Related Cancer Predisposition Cn377763?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
NCCN Genetic/Familial High-Risk Assessment: Breast, Ovarian, and Pancreatic. NCCN Guidelines Version 2.2023.
Lloyd A, Mitchell KJ, Garrett J. RAD51D-associated cancer predisposition: Review of the clinical phenotype. Cancer Genet. 2022;268-269:45-52.
Hart MR, Sayers C, Thompson BA. The role of RAD51D germline mutations in breast and ovarian cancer susceptibility. J Mol Diagn. 2021;23(4):432-441.
Gomez-Garcia EB, de Boer AM, Oosterwijk JC, et al. Phenotypic characterization of RAD51D mutation carriers. Fam Cancer. 2020;19(3):225-231.
Medication Comparisons
Compare medications used to treat Rad51d Related Cancer Predisposition Cn377763. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy