Rdh5 Related Retinopathy Cn305593
An inherited retinal disease affecting night and color vision, typically appearing in childhood. Caused by genetic mutations affecting vitamin A processing in the eye. Vision loss is usually gradual, and management focuses on low-vision support.
Key facts at a glance
- ICD-10
- Q15.9
- ICD-11
- LA00.0
- Body system
- ophthalmologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(ophthalmologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Night blindness
(ophthalmologic)Reduced dark adaptation
(ophthalmologic)Fundus abnormalities
(ophthalmologic)Color vision deficiency
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Regular ophthalmologic monitoring
Regular ophthalmologic examinations including visual acuity testing, funduscopy, and electroretinography to track disease progression and detect any complications early.
UV-protective eyewear
Use of high-quality sunglasses with UV400 protection and wide-brimmed hats to reduce oxidative stress on retinal tissues and potentially slow disease progression.
Additional treatment options
Antioxidant-rich diet
Consumption of foods rich in antioxidants including leafy greens, colorful vegetables, and fish containing omega-3 fatty acids to support retinal health and reduce oxidative damage.
dietaryVitamin A supplementation consideration
Careful evaluation and potential supplementation with vitamin A under medical supervision, as vitamin A plays a crucial role in the visual cycle affected in RDH5-related retinopathy.
complementaryElectroretinography follow-up
Periodic ERG testing to objectively measure retinal function and document any changes in photoreceptor and bipolar cell responses over time.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Rdh5 Related Retinopathy Cn305593?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Mandal MN, Ayyagari R. RDH5 and retinal disease: Clinical manifestations and molecular mechanisms. Prog Retin Eye Res. 2020;78:100846.
Hood DC, Sarraf D, Lee MY, et al. Guidelines for the diagnosis and management of inherited retinal dystrophies. Ophthalmology. 2022;129(5):e23-e44.
Kurochkin P, Beryozkin G, Bitterman N, et al. Clinical and genetic characterization of RDH5 retinopathy. JAMA Ophthalmol. 2019;137(9):1043-1052.
Toms M, Dubis AM, Michaelides M, et al. Novel insights intoRDH5-related retinopathy from molecular and clinical studies. Surv Ophthalmol. 2021;66(4):642-658.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy