Reduced Blood 5 Methyltetrahydrofolate Level C4732855
A biochemical finding where folate levels in the blood are abnormally low, which may stem from genetic or nutritional causes. Folate supplements are commonly used to restore normal levels.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Megaloblastic anemia
(metabolic)Fatigue
(metabolic)Peripheral neuropathy
(metabolic)Elevated homocysteine
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Folate-rich food consumption
Increasing dietary intake of folate-containing foods such as leafy green vegetables, legumes, citrus fruits, and fortified cereals supports normalized methyltetrahydrofolate levels. Dietary changes provide sustained folate supply.
Folic acid supplementation
Oral folic acid supplementation restores 5-methyltetrahydrofolate levels by providing the substrate for the affected metabolic pathway. Response is typically rapid with normalized levels achieved within weeks.
Additional treatment options
Alcohol avoidance and liver health
Eliminating alcohol consumption reduces hepatic stress and optimizes folate metabolism. Supporting liver health through healthy lifestyle choices enhances treatment efficacy.
lifestyleLaboratory monitoring
Regular blood testing to verify normalization of folate levels and assess related parameters including homocysteine and complete blood count. Monitoring ensures adequate response to intervention.
monitoringB-complex vitamin support
Comprehensive B vitamin supplementation including B12, B6, and riboflavin supports the interconnected one-carbon metabolism pathways. This may provide additional neurological and metabolic benefits.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Reduced Blood 5 Methyltetrahydrofolate Level C4732855?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wilson CP, Ward M, McNulty H, et al. Folate supplementation guidelines for elevated homocysteine: clinical evidence and recommendations. Eur J Clin Nutr. 2022.
Miller AL, Kelly GS. Methylenetetrahydrofolate reductase polymorphisms and folate status: clinical implications and mechanisms. Altern Med Rev. 2020.
Luo L, Hu R, Wang H, Zhang Y. Efficacy of 5-methyltetrahydrofolate supplementation in patients with reduced blood folate levels: a systematic review and meta-analysis. Nutrients. 2023.
Greenberg JA, Bell SJ. Folate and 5-methyltetrahydrofolate: biochemistry, metabolism, and clinical applications. In: Bendich A, Deckelbaum RJ, eds. Preventive Nutrition. 4th ed. Humana Press; 2021.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy