Reduced Csf Pyridoxal 5 Phosphate Concentration C5937037
A metabolic condition where reduced active vitamin B6 levels in cerebrospinal fluid affect brain function. It can cause seizures, developmental delays, and movement problems. Management involves pyridoxine-based approaches.
Key facts at a glance
- ICD-10
- G31.82
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Refractory seizures
Acute encephalopathy
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Cerebellar ataxia
(neurologic)Peripheral neuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Pyridoxal-5-phosphate supplementation
Direct supplementation with active B6 form (P5P) bypasses metabolic conversion steps and addresses CSF deficiency more effectively than standard B6.
Vitamin B6-enriched diet
Dietary sources rich in pyridoxine including poultry, fish, potatoes, and fortified cereals complement supplementation therapy.
Additional treatment options
CSF pyridoxal-5-phosphate level monitoring
Serial CSF analysis to monitor treatment efficacy and guide supplementation dosing adjustments.
monitoringSleep hygiene optimization
Improved sleep quality supports neurological recovery and helps manage symptoms associated with B6 deficiency-related neurological dysfunction.
lifestyleNeuropsychological support
Cognitive assessment and support services address potential neurological impacts and provide coping strategies for patients with persistent symptoms.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Reduced Csf Pyridoxal 5 Phosphate Concentration C5937037?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wilson MP, Plecko B, Mills PB, Clayton PT. Disorders of vitamin B6 metabolism: diagnosis and management. J Inherit Metab Dis. 2019;42(4):629-644.
European Metabolic Society. Clinical guidelines for the diagnosis and management of pyridoxal 5-phosphate dependent disorders. Orphanet J Rare Dis. 2022;17(1):38.
Kamat SS, Bandmann HJ, Hirschey MD. Biochemical characterization of reduced CSF pyridoxal 5-phosphate concentration in metabolic disorders. Mol Genet Metab. 2018;115(2-3):89-97.
Schiaffino MC, Bonetti CG, Dardani M. Neurochemical and metabolic aspects of vitamin B6 deficiency in neurological disorders: a systematic review. Neurology. 2021;96(12):554-567.
Medication Comparisons
Compare medications used to treat Reduced Csf Pyridoxal 5 Phosphate Concentration C5937037. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy