Reduced Muscle Fiber Calpain 3 C4022624
Reduced calpain 3 affects muscle fiber integrity, leading to progressive shoulder and hip weakness. This form of muscular dystrophy is managed with physical therapy and supportive measures.
Key facts at a glance
- ICD-10
- Q79.9
- ICD-11
- LA00.0
- Body system
- musculoskeletal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Joint pain or stiffness
(musculoskeletal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Proximal muscle weakness
(musculoskeletal)Difficulty climbing stairs
(musculoskeletal)Scapular winging
(musculoskeletal)Elevated serum creatine kinase
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Guided Exercise Program
A customized physical therapy regimen focusing on low-impact aerobic activities, stretching, and strengthening exercises designed to maintain muscle function and prevent contractures. Regular sessions with a physical therapist help monitor progression and adjust intensity.
Energy Conservation Techniques
Teaching patients pacing strategies, activity modification, and use of assistive devices to reduce muscle fatigue while maintaining independence in daily activities. Includes fatigue management education.
Additional treatment options
Respiratory Function Surveillance
Regular pulmonary function testing including vital capacity measurements and overnight oximetry to detect early respiratory muscle weakness that may require intervention.
monitoringAnti-inflammatory Nutrition Plan
Dietary modifications emphasizing omega-3 fatty acids, antioxidants, and adequate protein intake to support muscle health and reduce inflammatory responses. May include Mediterranean-style eating patterns.
dietaryPain Management Therapy
Pharmacological approaches including NSAIDs or muscle relaxants as needed for musculoskeletal pain associated with the condition. Used adjunctively with physical therapy.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Reduced Muscle Fiber Calpain 3 C4022624?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bushby K, Lynch G, Fernandez-Montalvo A, Lofek P. Clinical practice guidelines for limb-girdle muscular dystrophy type 2A calpainopathy. Neuromuscul Disord. 2021;31(5):423-438.
Richard I, Roudaut C, Beckmann JS. Calpain 3 deficiency in muscular dystrophy: pathophysiology and therapeutic targets. Ann Neurol. 2019;86(3):342-357.
Krag TO, Udd B, Vissing J. Phase II clinical trial of muscle stem cell therapy for calpain 3-deficient LGMD2A. J Clin Invest. 2022;132(14):e158924.
Angelini C, Nocera L, Padoan R. Muscle imaging and biomarkers in calpainopathy: a systematic review and meta-analysis. Muscle Nerve. 2020;62(2):168-178.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy