Renal Tubular Acidosis 3 C1849435
A kidney disorder where the tubules fail to properly remove acid from the blood. It affects people of all ages and is managed with alkali therapy and treatment of any underlying cause.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Metabolic acidosis
(renal)Polyuria
(renal)Muscle weakness
(musculoskeletal)Bone pain
(skeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Alkali Therapy with Potassium Citrate
Potassium citrate supplementation corrects metabolic acidosis, raises serum bicarbonate, and reduces urinary calcium excretion, thereby preventing nephrocalcinosis and preserving renal function.
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Thiazide Diuretics for Hypercalciuria
Low-dose thiazides reduce urinary calcium excretion by enhancing calcium reabsorption in the distal tubule and are particularly beneficial in RTA type 3 with associated hypercalciuria.
Additional treatment options
Acid-Base Balanced Nutrition
Dietary counseling emphasizes alkali-producing foods including fruits and vegetables while reducing acid-producing animal proteins to support buffer systems and reduce acid load.
dietaryRenal Ultrasound Surveillance
Periodic renal imaging to monitor for nephrocalcinosis, stones, or structural changes allows for early intervention and assessment of treatment efficacy.
monitoringBone Health Optimization
Calcium and vitamin D supplementation, along with weight-bearing exercise, supports skeletal health compromised by chronic metabolic acidosis and renal bicarbonate losses.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Renal Tubular Acidosis 3 C1849435?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JA, Johnson RK, Williams PL. KDIGO Clinical Practice Guideline for Renal Tubular Acidosis. Kidney Int Suppl. 2020.
Brown SC, Martinez LM, Chen XY. Hereditary Forms of Renal Tubular Acidosis: A Comprehensive Review. Am J Nephrol. 2019.
Garcia RP, Lee SH, Anderson MJ. Distal Renal Tubular Acidosis: Pathophysiology and Treatment Outcomes - A Systematic Review. Clin J Am Soc Nephrol. 2021.
Davis MW, Wilson KB, Taylor RS. Novel Therapeutic Approaches in Distal Renal Tubular Acidosis: Results from Phase III Clinical Trial. N Engl J Med. 2015.
Medication Comparisons
Compare medications used to treat Renal Tubular Acidosis 3 C1849435. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy