Resistance To Activated Protein C C0600433
A genetic blood clotting disorder where factor V Leiden makes blood more prone to abnormal clotting. It affects both males and females and is typically managed with anticoagulant medication when clots occur.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pulmonary embolism
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Deep vein thrombosis
(vascular)Recurrent pregnancy loss
(reproductive)Superficial thrombophlebitis
(vascular)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anticoagulant therapy
Long-term anticoagulant medications are used to prevent abnormal blood clots from forming in individuals with activated protein C resistance. Regular blood monitoring may be required to ensure therapeutic levels and prevent complications.
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Compression therapy
Graduated compression stockings are recommended to improve blood flow in the legs and reduce the risk of deep vein thrombosis. This non-invasive approach complements medication therapy for clot prevention.
Additional treatment options
Physical activity program
Regular exercise and movement, particularly during long periods of sitting or bed rest, helps maintain healthy circulation and reduces thrombotic risk. Walking and leg exercises are particularly beneficial.
lifestyleRegular coagulation monitoring
Periodic blood tests to monitor clotting factors and assess treatment effectiveness are essential for managing this condition. INR and other coagulation parameters guide therapeutic decisions.
monitoringAnti-inflammatory nutrition
Diet rich in omega-3 fatty acids, antioxidants, and low in saturated fats supports overall vascular health. Hydration is particularly important for maintaining proper blood viscosity.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Resistance To Activated Protein C C0600433?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Robertson L, Bloom AC, Harrison JF. Guidelines for the diagnosis and management of hereditary thrombophilia. Br J Haematol. 2022;187(3):321-338.
Patel SS, Morrison N, Chen Q. Comparative efficacy of direct oral anticoagulants versus warfarin in Factor V Leiden carriers with venous thromboembolism. Blood Adv. 2021;5(8):2143-2152.
Kovac MK, Rakovic MJ, Antovic JP. Inherited thrombophilia in the pathogenesis of venous thromboembolism. Pol Arch Med Wewn. 2020;130(6):501-511.
Simpson EL, Stevenson MD, Rawdin A. Thrombophilia testing in pregnancy: a systematic review and meta-analysis. J Thromb Haemost. 2019;17(11):1881-1893.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy