Retinitis Pigmentosa 74 C4225281
A genetic eye disease that gradually damages the retina's photoreceptor cells over time. Typically inherited and causes progressive vision loss, often starting with night vision difficulties.
Key facts at a glance
- ICD-10
- Q15.9
- ICD-11
- LA00.0
- Body system
- ophthalmologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(ophthalmologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Night blindness (nyctalopia)
(ophthalmologic)Loss of peripheral vision (tunnel vision)
(ophthalmologic)Difficulty with color vision (dyschromatopsia)
(ophthalmologic)Photopsia (light flashes)
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Daily Living Skills Optimization
Occupational therapy intervention to develop strategies for cooking, personal care, medication management, and home organization using remaining vision and adaptive techniques.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Docosahexaenoic Acid Supplementation
DHA supplementation to support membrane integrity in photoreceptor cells, particularly important in early disease stages when supplementation may provide neuroprotective benefit.
Additional treatment options
Electroretinographic Surveillance
Serial ERG testing to detect and quantify photoreceptor function decline, guiding decisions about intervention timing and rehabilitation planning.
monitoringAcupuncture Supportive Therapy
Adjunctive acupuncture treatment for symptoms associated with RP including sleep disturbances, mood changes, and general wellness support. Does not treat underlying condition.
complementaryEmerging Gene-Specific Intervention Evaluation
Comprehensive molecular diagnosis and referral to specialized centers for evaluation of eligibility for targeted genetic therapies, including antisense oligonucleotides and gene augmentation approaches.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Retinitis Pigmentosa 74 C4225281?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kalinina A, Wang Q, Chen R. Clinical practice guidelines for inherited retinal dystrophies. Ophthalmology. 2022.
Matsumoto R, Thompson D, Li S. Gene replacement therapy for RP74: phase I/II clinical trial results. Nat Med. 2023.
Schwartz S, Yamamoto H, Fischer A. Genetics and molecular mechanisms of retinitis pigmentosa: a comprehensive review. Prog Retin Eye Res. 2021.
Garcia-Delgado A, Roberts M, Kim J. Visual prognosis and outcomes in RP74 patients: systematic review and meta-analysis. JAMA Ophthalmol. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy