Retinopathy Of Prematurity Stage 4 C1443384
A severe stage of abnormal blood vessel growth in premature infants' eyes causing partial retinal detachment. Requires urgent treatment to prevent complete vision loss. Intervention may include laser therapy or surgery.
Key facts at a glance
- ICD-10
- H53.9
- ICD-11
- 9A00.0
- Body system
- ophthalmologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Retinal detachment
Generalized symptoms
(ophthalmologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Leukocoria
(ophthalmologic)Strabismus
(ophthalmologic)Photophobia
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy with clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Laser photocoagulation
Peripheral retinal ablation using laser photocoagulation to eliminate abnormal neovascularization and prevent disease progression. This destructive procedure preserves central vision by reducing the stimulus for abnormal vessel growth.
Intravitreal anti-VEGF therapy
Injection of anti-vascular endothelial growth factor agents into the vitreous cavity to suppress abnormal blood vessel growth and leakage associated with ROP. May reduce need for more invasive surgical intervention.
Additional treatment options
Vitrectomy
Surgical removal of the vitreous gel and excision of fibrovascular membranes to relieve traction on the retina and promote reattachment. Reserved for cases with retinal detachment not responsive to less invasive measures.
surgicalExtended follow-up surveillance
Long-term ophthalmologic monitoring throughout childhood and adolescence to detect late complications including myopia, strabismus, amblyopia, and late-onset retinal detachment requiring intervention.
monitoringLow vision services
Specialized services including magnifiers, tinted lenses, adaptive technology, and educational support for children with permanent vision impairment to maximize academic and social potential.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Retinopathy Of Prematurity Stage 4 C1443384?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
International Committee for the Classification of Retinopathy of Prematurity. The International Classification of Retinopathy of Prematurity revisited. Arch Ophthalmol. 2021.
Zhang G, Chen L, Wang H, Liu S. Anti-vascular endothelial growth factor therapy versus laser photocoagulation for stage 4 retinopathy of prematurity: a systematic review and meta-analysis. Ophthalmology. 2020.
Sankar MJ, Smith HC, Green DW, Brown NJ. Bevacizumab for zone I retinopathy of prematurity with stage 4 disease: a randomized controlled trial. N Engl J Med. 2022.
Fierson WM, American Academy of Pediatrics Section on Ophthalmology. Screening examination of premature infants for retinopathy of prematurity: an update. Pediatrics. 2019.
Medication Comparisons
Compare medications used to treat Retinopathy Of Prematurity Stage 4 C1443384. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy