Retinopathy Of Prematurity Stage 5 C1443385
The most severe stage of an eye disease in premature infants, where the retina becomes fully detached. This stage causes blindness and has very limited treatment options.
Key facts at a glance
- ICD-10
- H53.9
- ICD-11
- 9A00.0
- Body system
- ophthalmologic
- Severity
- critical
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Total retinal detachment
Leukocoria
Strabismus
(ophthalmologic)Nystagmus
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pars Plana Vitrectomy
Primary surgical intervention for Stage 5 ROP involving removal of the vitreous and scar tissue to reattach the retina and restore visual potential.
Standard interventional procedure protocol
Requires immediate emergency medical intervention. Do not delay treatment.
Scleral Buckling Procedure
Placement of a silicone band around the eye to support the retina and encourage reattachment in combination with or prior to vitrectomy.
Additional treatment options
Intravitreal Anti-VEGF Injection
Targeted injection of anti-vascular endothelial growth factor agents to reduce abnormal vessel proliferation and stabilize retinal detachment.
procedureLong-term Ophthalmological Follow-up
Extended monitoring for glaucoma, cataract, phthisis, and other complications requiring additional interventions.
monitoringLow Vision Rehabilitation Services
Specialized training and assistive devices to maximize functional vision and support developmental milestones in visually impaired children.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Retinopathy Of Prematurity Stage 5 C1443385?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fierson WM, Capone A Jr, American Academy of Pediatrics Section on Ophthalmology. Screening examination of premature infants for retinopathy of prematurity. Pediatrics. 2018;142(6).
Hartnett ME, McColm JR. Retinopathy of prematurity: advances in surgical management. Prog Retin Eye Res. 2020;78:100849.
Klufas MA, Patel SN, Ryan MC, et al. Comparison of outcomes after lens-sparing vitrectomy versus scleral buckling for stage 5 retinopathy of prematurity: a meta-analysis. JAMA Ophthalmol. 2021;139(8):847-856.
Quinn GE, Ying GS, Repka MX, et al. Outcomes of threshold and prethreshold retinopathy of prematurity: the cryotherapy versus laser therapy perspective. Curr Opin Ophthalmol. 2019;30(4):234-240.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy