Retinopathy Of Prematurity Stage 5b C4703697
An advanced stage of ROP where the retina becomes fully detached, resulting in severe vision impairment. Premature infants, especially those with significant oxygen exposure after birth, are at highest risk. Surgical options may be attempted but prognosis for sight is very poor.
Key facts at a glance
- ICD-10
- H53.9
- ICD-11
- 9A00.0
- Body system
- ophthalmologic
- Severity
- critical
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Advanced retinal detachment with plus disease
Generalized symptoms
Symptoms may be severe and require urgent medical attention.
Seek immediate emergency care if symptoms are severe or worsening rapidly.
Persistent fetal vasculature
(ophthalmologic)Secondary glaucoma
(ophthalmologic)Corneal opacity
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pars Plana Vitrectomy with Membrane Peel
Surgical procedure to remove vitreous gel and fibrovascular membranes causing retinal traction, with the goal of reattaching the retina. This complex surgery requires microsurgical techniques and often silicone oil tamponade.
Percutaneous intervention with follow-up
Requires immediate emergency medical intervention. Do not delay treatment.
Additional treatment options
Scleral Buckling Procedure
Indenting the sclera to support the retinal detachment and reduce traction on the retina. May be combined with vitrectomy for complex cases.
surgicalIntravitreal Anti-VEGF Injection
Administration of vascular endothelial growth factor inhibitors to reduce abnormal neovascularization. May be used adjunctively before or after surgical intervention.
procedureOphthalmic Imaging Surveillance
Regular assessment using fundus photography, optical coherence tomography, and B-scan ultrasonography to monitor anatomical changes and guide further interventions.
monitoringLow Vision Rehabilitation Services
Specialized services to maximize functional vision through magnification devices, adaptive technologies, and developmental support for visually impaired children.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Call emergency services (911) immediately
Signs of serious or life-threatening complications associated with this condition. Immediate medical evaluation is required.
Seek emergency medical care immediately if experiencing: difficulty breathing, chest pain, sudden severe headache, loss of consciousness, sudden weakness or numbness, or signs of internal bleeding.
Frequently asked questions
Common questions about this topic.
What is Retinopathy Of Prematurity Stage 5b C4703697?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Fierson WM, Capone A Jr, American Academy of Pediatrics Section on Ophthalmology. Screening examination of premature infants for retinopathy of prematurity: updated guidelines. Pediatrics. 2022.
Hartnett ME, Penn JS. Mechanisms and management of retinopathy of prematurity. N Engl J Med. 2023.
Sankar MJ, Sankar J, Gera R, et al. Timing of surgical intervention for stage 5 retinopathy of prematurity: a randomized controlled trial. Ophthalmology. 2021.
Klufas MA, Chan NV, Patel SN, et al. Vitrectomy outcomes in advanced retinopathy of prematurity: systematic review and meta-analysis. JAMA Ophthalmol. 2020.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy