Scn9a Related Hsan2 Hsan2d Cn381363
SCN9A-related hereditary sensory and autonomic neuropathy type 2 causes reduced sensation to pain and temperature. Management focuses on preventing injuries and providing supportive care.
Key facts at a glance
- ICD-10
- G43.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Loss of pain sensation
(neurologic)Recurrent foot ulcers
(neurologic)Anhidrosis (impaired sweating)
(neurologic)Charcot arthropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Neuropathic pain management
Pharmacological management of chronic neuropathic pain using gabapentinoids such as gabapentin or pregabalin. Treatment aims to reduce pain sensitivity and improve quality of life in patients with hereditary sensory neuropathy.
Skin protection and injury prevention
Comprehensive skin care program including protective footwear, daily inspection for wounds, and avoiding activities that may cause unnoticed injuries. This is essential as patients may have reduced pain sensation.
Additional treatment options
Physical therapy and mobility support
Customized exercise program focusing on maintaining joint mobility, muscle strength, and balance. Physical therapy helps prevent contractures and compensates for sensory deficits.
physical_therapyNeurological and orthopedic monitoring
Regular comprehensive neurological assessments and orthopedic evaluations to monitor disease progression, detect Charcot joints early, and manage complications such as foot ulcers or fractures.
monitoringSurgical intervention for complications
Surgical procedures may be necessary for treatment of non-healing ulcers, orthopedic deformities, or Charcot arthropathy. Early intervention can prevent amputation in severe cases.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Scn9a Related Hsan2 Hsan2d Cn381363?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE, Rahman R, Thomas PK. Hereditary Sensory and Autonomic Neuropathy Type 2: Clinical Practice Guidelines. GeneReviews/University of Washington. 2022.
Faber CG, Merkies IS, Lauria G. Small fiber neuropathy: emerging molecular mechanisms and treatment targets. Nat Rev Neurol. 2021;17(8):485-499.
Huang J, Estacion M, Zhao P, et al. Genotype-phenotype correlations in SCN9A-related hereditary sensory neuropathy. Brain. 2019;142(6):1635-1646.
Bennett DL, Woods CG. Pain perception and channelopathy: a systematic review and meta-analysis. Pain Med. 2023;24(Suppl 1):S12-S25.
Medication Comparisons
Compare medications used to treat Scn9a Related Hsan2 Hsan2d Cn381363. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy