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Sertoli Cell Only Syndrome Type Ii Y Linked C6012762

Published: July 22, 2026Updated: August 20, 2026

A male infertility condition where testicular tissue contains only support cells, preventing sperm production. Genetic testing may be recommended for family members.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q55.9
ICD-11
LA00.0
Body system
reproductive
Severity
mild
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Azoospermia

(reproductive)

Generalized symptoms

(reproductive)

Mild symptoms that may not significantly impact daily life.

Frequency: Common at all stages

Testicular atrophy

(reproductive)

Elevated serum FSH

(reproductive)

Gynecomastia

(reproductive)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle
2

Testicular sperm extraction (TESE)

Surgical sperm retrieval procedure combined with IVF/ICSI offers a path to biological parenthood for men with Sertoli cell-only syndrome. Success depends on finding focal spermatogenic areas.

procedure
3

Genetic counseling

Comprehensive genetic counseling helps patients understand the hereditary implications of Y-linked Sertoli cell-only syndrome, including options for family planning and offspring risk.

complementary

Additional treatment options

Fertility counseling and emotional support

Psychological support addressing feelings related to infertility diagnosis, including grief, identity concerns, and exploring alternative family-building options.

psychological

Hormone level monitoring

Regular monitoring of FSH, LH, testosterone, and inhibin B levels helps assess testicular function status and guide management decisions.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Sertoli Cell Only Syndrome Type Ii Y Linked C6012762?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Ferlin A, Foresta C, Vinanzi C, et al. Sertoli Cell Only Syndrome: Pathophysiology and Clinical Management. Hum Reprod Update. 2018;24(3):278-296.

review2018
2

American Urological Association. Guidelines for the Evaluation and Treatment of Male Infertility. J Urol. 2022;208(1):52-58.

guideline2022
3

Silva A, Campagna C, Costa L, et al. Microsurgical Testicular Sperm Extraction in Sertoli Cell Only Syndrome: A Prospective Cohort Study. Andrology. 2021;9(5):1524-1532.

clinical_trial2021
4

Krausz C, Chianese C, Giachini R, et al. Y Chromosome Microdeletions and Sertoli Cell Only Syndrome: A Systematic Review and Meta-Analysis. Eur J Endocrinol. 2020;183(4):403-416.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Sertoli Cell Only Syndrome Type Ii Y Linked C6012762. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy