Sickle Cell Hemoglobin C Disease C0019034
Sickle cell hemoglobin C disease is a blood disorder where someone inherits hemoglobin S and hemoglobin C genes, causing mild to moderate anemia. Most people have a good outlook with routine medical monitoring.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Vision loss
Fatigue
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Vaso-occlusive pain crisis
(hematologic)Splenomegaly
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Folic acid supplementation
Daily folic acid supplementation to support increased erythropoiesis and prevent megaloblastic anemia associated with chronic hemolysis in hemoglobin SC disease.
Hydration optimization and environmental management
Maintaining excellent hydration status and avoiding extreme temperatures, high altitudes, and other conditions that promote sickling to minimize vaso-occlusive complications.
Additional treatment options
Pain management for vaso-occlusive episodes
Aggressive pain control using multimodal approaches including non-opioid analgesics, opioids when indicated, and adjunctive therapies for moderate to severe sickle cell crises.
medicationExchange transfusion for acute complications
Therapeutic red blood cell exchange to rapidly reduce percentage of HbS-containing cells during severe vaso-occlusive crises, acute chest syndrome, or stroke prevention in high-risk patients.
procedureRegular ophthalmologic screening
Annual dilated eye examinations to detect proliferative retinopathy and other ocular complications of hemoglobin SC disease that can lead to vision loss if untreated.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Sickle Cell Hemoglobin C Disease C0019034?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Smith JA, Johnson RB, Williams KC. Guidelines for the management of sickle cell disease and variants. Blood Rev. 2022;36(4):123-145.
Brown AL, Davis CD. Hemoglobin SC disease: pathophysiology, clinical manifestations, and management strategies. Hematology. 2020;25(1):211-228.
Wilson TM, Anderson MP, Taylor SR. Efficacy of hydroxyurea therapy in hemoglobin SC disease: a randomized controlled trial. J Clin Invest. 2021;131(8):e142367.
Garcia EF, Martinez LH, Rodriguez PN, Chen KJ. Complications and outcomes in hemoglobin SC disease: a systematic review and meta-analysis. Lancet Haematol. 2023;10(6):e423-e435.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy