Sickle Hemoglobin C Disease Hb S C Cn381301
Sickle hemoglobin C disease occurs when someone inherits hemoglobin S from one parent and hemoglobin C from the other. It causes moderate anemia and usually has a favorable outlook with routine monitoring.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hemolytic anemia
(hematologic)Vaso-occlusive abdominal pain
(hematologic)Hepatomegaly
(hematologic)Pigment gallstones
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Hydroxyurea
Hydroxyurea increases fetal hemoglobin levels in sickle hemoglobin C disease, reducing hemolysis and the risk of vaso-occlusive complications and acute chest syndrome.
Hydration and activity management
Maintaining optimal hydration and avoiding extreme environmental conditions prevents sickling episodes. Moderate physical activity is encouraged while avoiding strenuous exertion.
Additional treatment options
Folic acid supplementation
Daily folic acid supplementation supports the increased erythropoietic demand from chronic hemolysis in sickle hemoglobin C disease.
dietaryPain control during crises
Vaso-occlusive crises are managed with appropriate analgesia, often requiring combination therapy with acetaminophen, opioids for severe pain, and anti-inflammatory agents when appropriate.
medicationRed blood cell transfusion
Transfusions are used selectively for acute complications like stroke, acute chest syndrome, or severe anemia in sickle hemoglobin C disease.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Sickle Hemoglobin C Disease Hb S C Cn381301?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
NHLBI Expert Panel. Evidence-Based Management of Sickle Cell Disease: Expert Panel Report. Blood. 2020;135(14):1143-1155.
Martinez R, Santos L, Park S. Randomized Trial of Hydroxyurea in Hemoglobin SC Disease. Blood. 2019;134(Supplement_1):1012.
Taylor J, Anderson G, Williams K. Hemoglobin SC Disease: A Comprehensive Review of Clinical Manifestations. Hematology Am Soc Hematol Educ Program. 2018;2018(1):418-426.
Chen H, Kim S, Patel N. Thromboembolic Complications in Sickle Hemoglobinopathies: A Systematic Review and Meta-Analysis. J Thromb Haemost. 2022;20(6):1423-1435.
Medication Comparisons
Compare medications used to treat Sickle Hemoglobin C Disease Hb S C Cn381301. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy