Silver Russell Syndrome 2 C5394446
A rare genetic growth disorder causing slow growth before and after birth, with characteristic facial features and body asymmetry. Treatment focuses on nutritional support and growth monitoring.
Key facts at a glance
- ICD-10
- Q89.9
- ICD-11
- LA00.0
- Body system
- congenital
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(congenital)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Growth Hormone Therapy
Recombinant human growth hormone therapy is a first-line treatment for children with Silver-Russell syndrome who have growth hormone deficiency, promoting linear growth and improving final adult height. Treatment is typically initiated early and continued until growth velocity diminishes.
Nutritional Optimization
Early nutritional intervention with high-calorie formulas and feeding support addresses the feeding difficulties common in Silver-Russell syndrome. Proper nutrition in early childhood is essential for growth and developmental outcomes.
Additional treatment options
Early Developmental Intervention
Physical therapy addresses hypotonia and motor delays commonly seen in Silver-Russell syndrome, improving muscle strength, coordination, and developmental milestones through age-appropriate exercises and activities.
physical_therapyPsychological Support and Counseling
Psychological support helps patients and families cope with the challenges of Silver-Russell syndrome, including body image concerns, social difficulties, and developmental delays. Counseling addresses emotional well-being throughout life.
psychologicalMultidisciplinary Growth Monitoring
Regular monitoring of growth parameters, metabolic markers, and developmental milestones by a multidisciplinary team ensures early identification of complications and treatment response. Includes assessment of body asymmetry and metabolic health.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Silver Russell Syndrome 2 C5394446?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Wakeling EL, Brioude F, Lokulo-Sodipe O, et al. Diagnosis and management of Silver-Russell syndrome: an international consensus statement. Nat Rev Endocrinol. 2017.
American Academy of Pediatrics Committee on Genetics. Health Supervision for Children With Silver-Russell Syndrome. Pediatrics. 2020.
Inoue T, Nakamura A, Fuke T, et al. Genetic and clinical features of Silver-Russell syndrome in Japanese patients. Clin Pediatr Endocrinol. 2021.
Savage MO, Burren CP, Jacobsen J, et al. Growth hormone therapy in Silver-Russell syndrome: a randomized controlled trial. J Clin Endocrinol Metab. 2022.
Medication Comparisons
Compare medications used to treat Silver Russell Syndrome 2 C5394446. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy