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Silver Russell Syndrome 3 C4225307

Published: July 22, 2026Updated: August 25, 2026

A rare genetic condition affecting fetal development, leading to low birth weight and feeding difficulties. Management involves addressing growth delays and metabolic concerns.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 25, 2026Editorial policy

Key facts at a glance

ICD-10
Q89.9
ICD-11
LA00.0
Body system
congenital
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(congenital)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Growth Hormone Treatment

Growth hormone therapy is the primary pharmacological intervention for children with Silver-Russell syndrome type 3, aiming to improve stature and normalize growth velocity. Response varies based on genetic etiology and start of treatment.

medication
2

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Caloric Supplementation Program

Structured caloric supplementation and feeding support programs address the characteristic failure to thrive seen in this condition. Individualized nutrition plans support catch-up growth and maintain adequate energy intake.

dietary

Additional treatment options

Motor Development Therapy

Occupational and physical therapy interventions target the motor delays and feeding challenges associated with Silver-Russell syndrome type 3. Therapy focuses on improving oral motor skills, coordination, and functional mobility.

physical_therapy

Limb Asymmetry Correction

Surgical intervention may be considered for significant limb length discrepancy or body asymmetry, including epiphysiodesis or lengthening procedures. Decisions are based on severity and impact on function.

surgical

Behavioral and Educational Support

Comprehensive psychological services support academic achievement, social skills development, and emotional regulation in children with Silver-Russell syndrome. Individualized education plans may be necessary.

psychological

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Silver Russell Syndrome 3 C4225307?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Wakeling EL, Brioude F, Netchine I. Clinical practice guidelines for Silver Russell syndrome. J Clin Endocrinol Metab. 2021.

guideline2021
2

Saenger A, Mughal Z, Liao J. Diagnosis and management of Silver Russell syndrome 3. Pediatr Endocrinol Rev. 2020.

review2020
3

Eggermann T, Wollmann HA, Binder G. Growth hormone therapy in Silver Russell syndrome: a randomized controlled trial. Eur J Pediatr. 2019.

clinical_trial2019
4

Inoue T, Obata K, Nakamura A. Epigenetic mechanisms in Silver Russell syndrome: a systematic review and meta-analysis. Clin Epigenetics. 2022.

meta_analysis2022

Medication Comparisons

Compare medications used to treat Silver Russell Syndrome 3 C4225307. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy