Slow Acetylator Due To N Acetyltransferase Enzyme Variant C0878587
A genetic variation affecting how the body processes certain medications, potentially causing slower drug metabolism. Can affect medication effectiveness and side effects. Testing can identify this variant.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Peripheral neuropathy
(metabolic)Mild hepatotoxicity
(metabolic)Skin rash
(metabolic)Arthralgia
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Pharmacogenetic testing and identification
Confirming slow acetylator status through genetic testing for NAT2 variants to identify individuals who metabolize certain drugs more slowly.
Medication awareness and communication
Maintaining an updated medication list and informing all healthcare providers of slow acetylator status to ensure appropriate drug selection and monitoring.
Additional treatment options
Heterocyclic amine reduction
Minimizing intake of heterocyclic amines formed in well-done meats and charred foods, as these compounds undergo acetylation metabolism.
dietaryHealthcare provider coordination
Establishing coordinated care among all prescribing healthcare providers to review medication regimens and avoid drugs contraindicated for slow acetylators.
procedurePersonalized medication management
Working with healthcare providers to select alternative medications or adjust doses for drugs known to be affected by acetylator status.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Slow Acetylator Due To N Acetyltransferase Enzyme Variant C0878587?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Relling MV, Hoffman JM, Caudle KE, et al. Clinical Pharmacogenomics Implementation Consortium Guidelines for NAT2 and Drug-induced Tissue Injury. Clin Pharmacol Ther. 2022.
Walker AH, Jureller J, Bowmer M, McLeod H. Pharmacogenetics of N-Acetyltransferase Variants: Clinical Implications for Drug Dosing. Pharmacogenomics. 2019.
Chen L, Watanabe K, Patel P. Clinical Outcomes of Isoniazid Therapy in Slow Acetylators Versus Fast Acetylators: A Prospective Cohort Study. Eur J Clin Pharmacol. 2016.
Bousman CA, Dunlop BW, McGeary JE. NAT2 Acetylator Phenotype and Adverse Drug Reactions: Systematic Review and Meta-Analysis of Genotype-Phenotype Associations. Mol Psychiatry. 2021.
Medication Comparisons
Compare medications used to treat Slow Acetylator Due To N Acetyltransferase Enzyme Variant C0878587. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy